4MEW,4I5J,4I5K


Conserved Protein Domain Family
PPP2R3
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cd21339: PPP2R3 
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serine/threonine protein phosphatase 2A regulatory subunit B"
Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This family includes PP2A regulatory B'' subunits alpha, beta and gamma, encoded by PPP2R3A, PPP2R3B and PPP2R3C, respectively. It also includes subunit delta encoded by PPP2R3D in mouse. These B-family regulatory subunits play various roles including regulation of cytoskeletal assembly, neuronal differentiation, mitogen-activated protein kinase signaling, and apoptosis. Subunits alpha and beta contain two-domain elongated structure with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity.
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Statistics
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PSSM-Id: 410336
Aligned: 4 rows
Threshold Bit Score: 388.092
Created: 23-Dec-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Ca binding siteCa binding site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Ca binding site 1 [ion binding site], 4 residue positions
Conserved feature residue pattern:D D [ND] [ED]Click to see conserved feature residue pattern help
Evidence:
  • Structure:4MEW: Homo sapiens serine threonine protein phosphatase 2A regulatory subunit B" subunit beta binds calcium ion
  • Structure:4I5K: Homo sapiens protein phosphatase 2 regulatory subunit B'' subunit alpha binds calcium ion
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
4MEW_A     86 DAAKFVHLLxs-pGCNYLVQEDFVPFLQDVVNTHpGLSFLKeasEFHSRYITTVIQRIFYAVNrswsgriTCAELRRssF 164 human
Q969Q6    171 HQTRIGLSLydvaGQGYLRESDLENYILELIPTLpQLDGLEk--SFYSFYVCTAVRKFFFFLDplrtgkiKIQDILAcsF 248 Homo sapiens
4I5J_A     12 DASKFICLLak-pNCSSLEQEDFIPLLQDVVDTHpGLTFLKdapEFHSRYITTVIQRIFYTVNrswsgkiTSTEIRKsnF 90  human
4I5K_A     12 DASKFICLLak-pNCSSLEQEDFIPLLQDVVDTHpGLTFLKdapEFHSRYITTVIQRIFYTVNrswsgkiTSTEIRKsnF 90  human

Feature 1                                          # # #      #                               
4MEW_A    165 LQNVALLEEeadinq--lteffSYEHFYVIYCKFWElDTDHDllidADDLARHndhalSTKXIDRIFSgavtrgrkvqke 242 human
Q969Q6    249 LDDLLELRDeelskesqetnwfSAPSALRVYGQYLNlDKDHNgmlsKEELSRYgtatmTNVFLDRVFQeclty------d 322 Homo sapiens
4I5J_A     91 LQTLALLEEeedinq--itdyfSYEHFYVIYCKFWElDTDHDlyisQADLSRYndqasSSRIIERIFSgavtrgktiqke 168 human
4I5K_A     91 LQTLALLEEeedinq--itdyfSYEHFYVIYCKFWElDTDHDlyisQADLSRYndqasSSRIIERIFSgavtrgktiqke 168 human

Feature 1                                                                                     
4MEW_A    243 gkisYADFVWFLISEEDKktptSIEYWFRcXDLDGDGalsxFELEYFYEEQCRRLDsxaiealpFQDCLCQXLDLVKprt 322 human
Q969Q6    323 gemdYKTYLDFVLALENRkepaALQYIFKlLDIENKGylnvFSLNYFFRAIQELMKihgqdpvsFQDVKDEIFDMVKpkd 402 Homo sapiens
4I5J_A    169 grmsYADFVWFLISEEDKrnptSIEYWFRcMDVDGDGvlsmYELEYFYEEQCERMEamgieplpFHDLLCQMLDLVKpav 248 human
4I5K_A    169 grmsYADFVWFLISEEDKrnptSIEYWFRcMDVDGDGvlsmYELEYFYEEQCERMEamgieplpFHDLLCQMLDLVKpav 248 human

Feature 1                                    
4MEW_A    323 egkiTLQDLKRCk---------lANVFFDTF 344 human
Q969Q6    403 plkiSLQDLINSnqgdtvttiliDLNGFWTY 433 Homo sapiens
4I5J_A    249 dgkiTLRDLKRCr---------mAHIFYDTF 270 human
4I5K_A    249 dgkiTLRDLKRCr---------mAHIFYDTF 270 human

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