Conserved Protein Domain Family
CH_PLS3_rpt3
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cd21331: CH_PLS3_rpt3 
third calponin homology (CH) domain found in plastin-3
Plastin-3, also called T-plastin, is an actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Plastin-3 contains four copies of the CH domain. This model corresponds to the third CH domain. CH domains are actin filament (F-actin) binding motifs.
Links
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Statistics
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PSSM-Id: 409180
Aligned: 6 rows
Threshold Bit Score: 298.453
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative actin
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                              #   #                                                     
P13797       377 YPALTKPENQDIDWTLLEGETREERTFRNWMNSLGVNPHVNHLYADLQDALVILQLYERIKVPVDWSK-VNKPPYPKLGA 455 human
XP_006008767 377 YPALSKPANQDIDWQLLEGETREERTFRNWMNSLGVSPHVNHLYGDLQDALVILQLYERTKVPVDWNK-VNKPPYAKLSA 455 coelacanth
NP_001006431 375 YPALTKPENQDIDWTLLEGETREERTFRNWMNSLGVNPHVNHLYGDLQDALVILQLYEKIKVPVDWNK-VNKPPYPKLGA 453 chicken
NP_001083581 375 YPALTKPVNQDIDWTLLEGETREERTFRNWMNSLGVNPHVNHLYNDLQDALVILQLYDKIKVPVDWSK-VNKPPYPKLGA 453 African clawed ...
NP_001002326 373 YPALTKPENQDINWGLLEGETREERTFRNWMNSLGVNPHVNHLYGDLQDALVILQLYEKIKVPVDWNNkVNKPPYPKLGA 452 zebrafish
XP_007890452 370 YPALQKPENQDIDWSLLEGETREERTFRNWMNSQGVNPQVNHLYSDLADALVILQLYEKIKVPVDWDR-VNRPPYPKLGA 448 elephant shark

Feature 1          # ##  ## #         #########    # ## ##  ##  #       
P13797       456 NMKKLENCNYAVELGKHPAKFSLVGIGGQDLNDGNQTLTLALVWQLMRRYTLNVL 510 human
XP_006008767 456 NMKKLENCNYAVELGKHAAKFSLVGIGGQDLNDGNPTLTLAVVWQLMRRYTLNVL 510 coelacanth
NP_001006431 454 NMKKLENCNYAVDLGKHPAKFSLVGIGGQDLNDGNPTLTLALVWQLMRRYTLNVL 508 chicken
NP_001083581 454 NMKKLENCNYAVDLGKHPAKFSLVGIGGQDLNDGNPTLTLALVWQLMRRYTLNVL 508 African clawed frog
NP_001002326 453 NMKKLENCNYAVELGKTKANFSLVGIGGQDLNDGNPTLTLALVWQLMRRYTLNVL 507 zebrafish
XP_007890452 449 NMKKLENCNYAVFLGKDSAKFSLVGIGGQDLNDGNETLTLALVWQLMRRYTLYVL 503 elephant shark

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