Conserved Protein Domain Family
CH_PLS2_rpt1

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cd21324: CH_PLS2_rpt1 
first calponin homology (CH) domain found in plastin-2
Plastin-2, also called L-plastin, or LC64P, or lymphocyte cytosolic protein 1 (LCP-1), is an actin-binding protein that plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-2 contains four copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.
Statistics
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PSSM-Id: 409173
Aligned: 3 rows
Threshold Bit Score: 296.15
Created: 9-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative actin
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                #   #                                                   
P13796        98 EGICAIGGTSEQSSVGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTNDLFNAVGDGIVLCKMINLSVPDTIDE 177 human
NP_001008440  95 EGICAIGGTSEQSSAGTQHSYSEEEKYAFVNWINKALEKDPDCKHVVPMNPETDDLFQAVGDGIVLCKMINFSVPDTIDE 174 chicken
XP_014354252  99 EGICAIGGTSQQSSAWTLHSYSEEEKYAFVNWINKALENDPDCKHVIPMDPNTDDLFKAVGDGIVLCKMINFSVPDTIDE 178 coelacanth
Feature 1                   # ##  ## #        #########    # ## ##  ##  #         
P13796       178 RTINKKKLTPFTIQENLNLALNSASAIGCHVVNIGAEDLKEGKPYLVLGLLWQVIKIGLFADIEL 242 human
NP_001008440 175 RTINKKKLTPFTIQENLNLALNSASAIGCHVVNIGAEDLKEGKPYLVLGLLWQVIKIGLFADIEI 239 chicken
XP_014354252 179 RTINKKKLTPFTIQENLNLALNSASAIGCHVVNIGAEDLKEGKPYLVLGLLWQVIKIGLFADIEL 243 coelacanth

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