Conserved Protein Domain Family
CH_dFLNA-like_rpt2
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cd21315: CH_dFLNA-like_rpt2 
second calponin homology (CH) domain found in Drosophila melanogaster filamin-A (dFLNA) and similar proteins
Drosophila melanogaster filamin-A (dFLNA or dFLN-A), also called actin-binding protein 280 (ABP-280) or filamin-1, is involved in germline ring canal formation. It may tether actin microfilaments within the ovarian ring canal to the cell membrane and contributes to actin microfilament organization. dFLNA contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.
Links
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Statistics
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PSSM-Id: 409164
Aligned: 9 rows
Threshold Bit Score: 227.742
Created: 18-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative actin
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                             #   #                                               # ##  ##
Q9VEN1        125 MWDGEDDKqln----gsGHTPKQRLLNWIHAKIPDlPINNFTNDWTTGKAVGALVDACAPGLCPDWelWDPKDAVQNASE 200  fruit fly
EEC07535      145 MWEGDDDSafd----ksGPTPKQRLLRWIQSKLPEkPITNFTSDWNDGTAVGALVDALAPGLCPNWatWDPKNALKNAKE 220  black-legged ...
EFX86436      127 MWEGDDGSrd-----gkGPTPKQRLMGWIQSKIPDmPITNFTNDWNDGRAIGALVDGVAPGLCPDWsdWDPKDALQNATE 201  common water ...
XP_030546012  146 VWEGEDDFd-------pSLSPKQRLLKWIQNKIPDvPVNNFTTDWNDGKAIGALVDAMGPGLCPDYknSQPEDNVKNIGK 218  Rhodamnia arg...
AKS48135      143 MWEGEEPGpq-----egGPTPKQRLLNWVQSKVPDiPIKNFNNDWNNGKAIGALVDAVGPGLCPDWedWDPKNAKKNAKE 217  Mytilus coruscus
XP_013408320  139 MWEGDEPDedrkkrgkeGPTPKQRLLGWIQGKVPDlPISNFTSDWNDGRAIGALVDAMGPGLCPDWedWNPKNAVENAKE 218  Lingula anatina
ELU02482      127 MWEDEEGHpdt---gnkDKTPKQRLLDWIQSKVPDrPITNFTSDWKDGKVVGALVDALAPGLCPDWedWNPKDGVKNAKE 203  Capitella teleta
XP_006811450  144 MWEDEGEGieq---kgrAPTPKERLMGWINSKLPDnPIRNFTTDWNSGKAIGALVDAVAPGLCPDWedWDPANALDNARE 220  Saccoglossus ...
XP_030827869  148 MWDDDGDMssd----kkKQSPKEKLLGWINGKVPDtPIHNFNKDWNNAKAIGALVDALAPGLCPDWedWSPKDALKNATE 223  purple sea ur...

Feature 1          #        #########      # ## ##  ##  #   
Q9VEN1        201 AMGLADDWLNVRQLIKPEELVNPNVDEQSMMTYLSQYPNSKL 242  fruit fly
EEC07535      221 AMDLASEWLGVPQLVTPEDMVNPKVDELSMMTYLAQFPNAKL 262  black-legged tick
EFX86436      202 AMGLADDWLKIPQLVKPEEMVNPNVDELSMMTYLSQYPNAKL 243  common water flea
XP_030546012  219 ALQLAEDWLDVPQLIKPKEMANRKVDELSMMTFLSQFPGAKL 260  Rhodamnia argentea
AKS48135      218 AMDAAEKWLDVPQLIKPDEMTNPKIDEMSMMTYLAQFPKAKL 259  Mytilus coruscus
XP_013408320  219 AMEAAEKYLGVPQLIKPAEMCNPKVDDLSMMTYLSQFPNAKL 260  Lingula anatina
ELU02482      204 AMDAAQQWLDVPQLIKPEEMCNPKVDDLSMMTYLSQFPNAKL 245  Capitella teleta
XP_006811450  221 AMKAAEDWLDVPQVMRPEDMVNPKVDDLSMMTYLSKFPSAKL 262  Saccoglossus kowalevskii
XP_030827869  224 AMKLAEDWLDVPQVLRPEDMVNPAVDDLSMMTYLSAFPKAKL 265  purple sea urchin

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