Conserved Protein Domain Family
CH_PARVG_rpt2
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cd21307: CH_PARVG_rpt2 
second calponin homology (CH) domain found in gamma-parvin
Gamma-parvin probably plays a role in the regulation of cell adhesion and cytoskeleton organization. It contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.
Links
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Statistics
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PSSM-Id: 409156
Aligned: 7 rows
Threshold Bit Score: 181.396
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative actin
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        #   #                                                     # ##  
Q9HBI0       196 DVFDELFKLaPEKVNAVKEAIVNFVNQKLDRLGlsvqNLDTQFADGVILLLLIGQLEGFFLHLkeFYLTPNSPAEMLHNV 275 human
OCT86057     191 DAFDHLFEQnPEKVEDVKKAIINFVNKHLVNLSltvtELESQFADGVILLLLIGQLEGYFMNLssFFLTPGTQEDKVHNV 270 African clawed ...
TRZ17858     513 EYITEKNCA-PDKLDAVKKALLKFVDQHVGKLGlnvkDIESQFSDGVVLLLLIGQLEGFFLNLrnFFLTPASTMEMLHNV 591 Zosterops borbo...
NP_001279419 185 DAIDNLFTLgPDKMNTVKQALLHLTNNRVQRLGitvnEFDSQFANGVILILLIGQLEGYFIRLseYHLSPSSHKEMLHNV 264 elephant shark
NP_001083007 192 CPIDELFKLeAHKIETVKKAILHFVNKNMASLGlnvtDLDKQFADGVILLLLIGQLEDFFIPLcdFFLCPVSSSEMLHNV 271 zebrafish
XP_020374488 199 DGINDLFKLgPDKVKIVQQAMLHFANKHLGGLGvvvkDLTTQFSNGVILILLIGQLEGYFIHLseYFLNPSDYNEKLYNV 278 whale shark
XP_014353241 202 DVFDDLFELvPDKINTVKQAILHFVNKHLTNLGlsvkDMDTQFADGVILLLLIGQLQGFFIHLgeFHLNPDTNSQMLQNI 281 coelacanth

Feature 1        ## #        #########    # ## ##  ##  #   
Q9HBI0       276 TLALELLKDEGLLSCPVSPEDIVnKDAKSTLRVLYGLFCKHT 317 human
OCT86057     271 SLALDLLLEGGIIENPINPADIVnGDLKATLRLLYGLFLRHK 312 African clawed frog
TRZ17858     592 NLAMELMAEGGLLNFPVNSEDIVnGDTKTIMRVLYCLYSKYR 633 Zosterops borbonicus
NP_001279419 265 TLALEILKESGVSIESVTPEDIVnMDSKATFRVLYALFTMYK 306 elephant shark
NP_001083007 272 TLALDLLIDRGFPVQSVDPQDIVsQDVPATVKVLYYLFNRHK 313 zebrafish
XP_020374488 279 TFVVELLKERELLKHPIDPADIVnMDSKATIRILHCLFAKYK 320 whale shark
XP_014353241 282 TLALDLLKESKLLQYPVKPEDILnKDVKATIRALHSLFSKYK 323 coelacanth

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