1RT8


Conserved Protein Domain Family
CH_FIMB_rpt2
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cd21297: CH_FIMB_rpt2 
second calponin homology (CH) domain found in Saccharomyces cerevisiae fimbrin and similar proteins
Fimbrin binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Members of this family contain four copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.
Links
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Statistics
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PSSM-Id: 409146
Aligned: 8 rows
Threshold Bit Score: 226.29
Created: 9-Oct-2019
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative actin
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #   #                                                   # ##  ## #    
1RT8_A        152 ETLDQFLRLPPEKILLRWFNYHLKAANWPRTVsNFSKDVSDGENYTVLLNQLAPELCsr-aPLQTTDVLQRAEQVLQNAE 230  fission yeast
462098        279 ETLEQFLRLPPEQILLRWFNYHLKQANWNRRVtNFSKDVSDGENYTILLNQLDPALCsk-aPLQTTDLMERAEQVLQNAE 357  baker's yeast
O59945        253 ETLDQFLRLPPEKILLRWFNYHLKAANWPRTVsNFSKDVSDGENYTVLLNQLAPELCsr-aPLQTTDVLQRAEQVLQNAE 331  fission yeast
OCK73571      281 ETLEQFLRLPPEQILLRWFNYHLKNAKWHRTVsNFSSDVKDGENYTVLLNQLAPETCsr-aPLQIRDLLQRAEQVLENAD 359  Lepidopterell...
KAA1084094    263 ETLDEFLRLPPDQILLRWFNYHLKAANWNRRVsNFSRDICDSENYTVLLNQLMPDHCsr-aPLQESNLEQRAEQVLQNAE 341  Puccinia gram...
CCJ29912      123 ETLDQFLRLPPEQILLRWFNFHLEAAKWHRRVsNFSADVSDGENYTILLNQLNPGECsr-ePLQIIDLLERAEKILSLAE 201  Pneumocystis ...
XP_023926296  290 ETLEQFLRLPPEQILLRWFNYHLKNAKWPRKVqNFSKDVQDGENYTVLLNQLAPSICsr-gPLQTSDLHQRAEQVLQNAD 368  Quercus suber
XP_022204529  279 ETLEQFLRLPPEKILLRWFNYHLKAANWPRRVtNFSNDVKDGENYTVLLAQIGSEYGctrkPLQTRYLLQRAEEVLLESE 358  brown plantho...

Feature 1              #########    # ## ##  ##  #
1RT8_A        231 Kl--dCRKYLTPTAMVAGNPKLNLAFVAHLFN 260  fission yeast
462098        358 Kl--dCRKYLTPSSLVAGNPKLNLAFVAHLFN 387  baker's yeast
O59945        332 Kl--dCRKYLTPTAMVAGNPKLNLAFVAHLFN 361  fission yeast
OCK73571      360 Rl--dCRKFLTPTSLVAGNPKLNLAFVANLFN 389  Lepidopterella palustris CBS 459.81
KAA1084094    342 Ki--gCRKFLTSKSIVAGNPKLNLAFVANLFN 371  Puccinia graminis f. sp. tritici
CCJ29912      202 Ki--dCRKYLTPSALVSGNPKLNLAFVAHLFN 231  Pneumocystis jirovecii
XP_023926296  369 AldppCRKFLTPTSLVAGNPKLNLAFVANLFN 400  Quercus suber
XP_022204529  359 Kl--dCHKFLTPKSLVAGNPKLNLAFVANLFN 388  brown planthopper

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