1WYN


Conserved Protein Domain Family
CH_CNN2
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cd21283: CH_CNN2 
calponin homology (CH) domain found in calponin-2
Calponin-2 (CNN2), also called neutral calponin, or smooth muscle calponin H2, is an actin cytoskeleton-associated regulatory protein that inhibits the activity of myosin-ATPase and cytoskeleton dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.
Links
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Statistics
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PSSM-Id: 409132
Aligned: 6 rows
Threshold Bit Score: 217.106
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative actin
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #   #                                                # ##  ## #         #####
1WYN_A        15 DPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLF 94  human
Q99439        27 DPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLF 106 human
NP_001135728  27 DPQKEAELRTWIESVTGRQIGADFQKGLKDGVILCELMNKLQPNSVRKINRSALNWHQLENLSNFIKAMVSYGMNPVDLF 106 chicken
ABG49505      26 DPQKETELKVWIEEVTGMSIGPDFQKGLKDGIILCELMNKLRPNSIPKVNVSRQNWHQLENLSNFIKTMALYGMKSVDLF 105 African clawed ...
AAZ14863      26 DPQREEELRIWIENTTGRSIGDDFQKGLKNGVILCELINKLQPGSVKKINQSSQNWHQLENLTNFIKAITTYGLKPHDIF 105 zebrafish
XP_005996391  27 DHQKEAELRLWIEDLTAKQIGDNFQMGLKNGVILCELINKLQPGSIKKINTSKQNWHQLENLSNFIKAITAYGLKTNDIF 106 coelacanth

Feature 1        ####     # ## ##  ##  #      
1WYN_A        95 EANDLFESGNMTQVQVSLLALAGKAKTKG 123 human
Q99439       107 EANDLFESGNMTQVQVSLLALAGKAKTKG 135 human
NP_001135728 107 EANDLFESGNLTQVQVSLLALAGMAKTKG 135 chicken
ABG49505     106 EANDLFENGNMTQVQVSLLALAGLAKTQG 134 African clawed frog
AAZ14863     106 EANDLFENGNMTQVQTTLLALAGMAKTKG 134 zebrafish
XP_005996391 107 EANDLFESGNMTQVQTTLLALAGMAKTKG 135 coelacanth

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