Conserved Protein Domain Family
CH_LRCH2
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cd21271: CH_LRCH2 
calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 2
Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2) may play a role in the organization of the cytoskeleton. It contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.
Links
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Statistics
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PSSM-Id: 409120
Aligned: 6 rows
Threshold Bit Score: 215.563
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative actin
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #   #                                                      # ##  ## #      
Q5VUJ6       643 REEREQIRQLRNNLESRLKViLPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKL 722 human
KFQ57756     231 REERELVEQLRENIETRLKIcLPEDLGSALMDGVVLCHLVNHVRPRSVGSIHVPSPAVPKLSMAKCRRNVENFLDACRKL 310 Dalmatian pelican
CDQ78267      38 REELELMEQLRDSIESRLKVaLPEDLGSSLMDGVVLCHLANHIRPRSVVSIHVPSPAVPKLSMAKCRRNVENFLDACRKM 117 rainbow trout
XP_007890444 655 REELEVIKHLKQNLEMRLKVmLPEDVGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKL 734 elephant shark
NP_001016380 626 REEREQINQLRNNLESRLKViLPEDIGAALMDGVVLCHLANHIRPRSVGSIHVPSPAVPKLSMAKCRRNVENFLEACKKL 705 tropical clawed...
XP_006007705 596 REELELIEQLRESIEARLKIdLPGELGAALMDGVVLCHLVNHIRPRSVGSIHVPSPAVPKLSMAKCRRNVENFLDACRKM 675 coelacanth

Feature 1           #########     # ## ##  ##  #
Q5VUJ6       723 GVSQERLCLPHHILEERGLVKVGVTVQALLE 753 human
KFQ57756     311 GIPEEKLCLPHHILEEKGLVKVSITVQALLD 341 Dalmatian pelican
CDQ78267     118 GVPEDKLCLPHHILEEKGMIKVSVTVQALVD 148 rainbow trout
XP_007890444 735 GVPEDKLCLPHHILEERGLVKVGTTVQALLE 765 elephant shark
NP_001016380 706 GVPQDHLCLPHHILEERGLVKVGVTVQALLE 736 tropical clawed frog
XP_006007705 676 GVPEEKLCLPHHILEEKGLVKVSITVQALLD 706 coelacanth

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