2JV9


Conserved Protein Domain Family
CH_SMTNL1
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cd21260: CH_SMTNL1 
calponin homology (CH) domain found in smoothelin-like protein 1
Smoothelin-like protein 1 (SMTNL1), also called calponin homology-associated smooth muscle protein (CHASM), plays a role in the regulation of contractile properties of both striated and smooth muscles. It can bind to calmodulin and tropomyosin. When it is unphosphorylated, SMTNL1 may inhibit myosin dephosphorylation. SMTNL1 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.
Links
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Statistics
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PSSM-Id: 409109
Aligned: 4 rows
Threshold Bit Score: 260.402
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative actin
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #   #                                                 # ##  ## #        #######
2JV9_A         4 GSKNMLLEWCRAMTRnYEHVDIQNFSSSWSSGMAFCALIHKFFPEAFDYAeLDPAKRRHNFTLAFSTAEKLADCAQLLEV 83  house mouse
A8MU46       379 GVKNMLLEWCRAMTKkYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAeLDPAKRRHNFTLAFSTAEKLADCAQLLDV 458 human
XP_029431247 281 GVKSMLLEWCRAKTRgYEHVDIQNFSSSWSSGMAFCALIHKFFPDSFDYEsLDPKNRRHNFELAFSAAEKHADCAPLLEA 360 two-lined caeci...
EMP27901     151 AIKNMLLEWCRAKTRgYEHVDIQNFSSSWSSGLAFCALIHKFFPDAFDYTaLDPANRRENFALAFATAEQHADCAPLLEV 230 Green sea turtle

Feature 1        ##       # ## ##  ##  #             
2JV9_A        84 DDMVRLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK 119 house mouse
A8MU46       459 DDMVRLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK 494 human
XP_029431247 361 EDMVRMSVPDSKCVYTYVQELYRSLVEKGLVKTKKQ 396 two-lined caecilian
EMP27901     231 EDMVRMSFPDSKCVYTYIQELYRSLVDKGLVKTKKK 266 Green sea turtle

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