Conserved Protein Domain Family
CH_CYTSB
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cd21257: CH_CYTSB 
calponin homology (CH) domain found in cytospin-B
Cytospin-B, also called nuclear structure protein 5 (NSP5), or sperm antigen HCMOGT-1, or sperm antigen with calponin homology and coiled-coil domains 1 (SPECC1), is a novel fusion Cytospin-B that contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.
Links
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Statistics
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PSSM-Id: 409106
Aligned: 5 rows
Threshold Bit Score: 253.799
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative actin
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #   #                                                 # ##  ## #       #
Q5M775        956 LAREYGGSKRNALLKWCQKKTQGYaNIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELnSQEKKRNLLLAFEAAESVGI 1035 human
TFK12829      189 LAREYGGSKRNALLKWCQKKTEGYpNIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELnGQEKKRNLLLAFQAAESVGI 268  big-headed tu...
XP_030041666  802 LAREYGGSKRNGLLKWCQRKTEGYpNIDITNFSSSWSDGLALCALLHTYLPAHIPFQELsSQNKKRNFLLAFQAAESVGI 881  Microcaecilia...
XP_014346072  950 LARAYGGSKRNALLKWCQQKTEGYqNIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELsSQDKKRNLMLAFQAAESVGI 1029 coelacanth
KAA0716313    909 LAREYGGSKRNALLKWCQKKTEGYpNIEVTNFSSSWSDGLAFCALLHTYLPAHIPYQELiSQDKGRNLTLAFQAAESIGI 988  Triplophysa t...

Feature 1         ########       # ## ##  ##  #   
Q5M775       1036 KPSLELSEMLyTDRPDWQSVMQYVAQIYKYFE 1067 human
TFK12829      269 KPSLELSEMMyTDRPDWQSVMQYVAQIYKYFE 300  big-headed turtle
XP_030041666  882 KPSLELSEMIyTDRPDWQRVMQYVAQIYKYFE 913  Microcaecilia unicolor
XP_014346072 1030 KPALEITDMVnTDRPNWQSVMQYIAQIYKYFE 1061 coelacanth
KAA0716313    989 KPSLDIDEMMhTDRPDWQRVMQYVSQIYKYFE 1020 Triplophysa tibetana

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