Conserved Protein Domain Family
CH_PARV_rpt1

?
cd21221: CH_PARV_rpt1 
first calponin homology (CH) domain found in the parvin family
The parvin family includes alpha-parvin, beta-parvin, and gamma-parvin. Alpha-parvin, also called actopaxin, calponin-like integrin-linked kinase-binding protein (CH-ILKBP), or matrix-remodeling-associated protein 2, plays a role in sarcomere organization and in smooth muscle cell contraction. It is required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Beta-parvin, also called affixin, is an adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases Cdc42 and Rac1 by guanine exchange factors, such as ARHGEF6. Both alpha-parvin and beta-parvin are involved in the reorganization of the actin cytoskeleton and the formation of lamellipodia, and both play roles in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. Gamma-parvin probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Members of this family contain two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.
Statistics
?
PSSM-Id: 409070
Aligned: 13 rows
Threshold Bit Score: 135.864
Created: 9-Oct-2019
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
 
putative actin
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.

cd21221 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd21221 is a member of the superfamily cl00030
Sub-family Hierarchy
cd00014CH_SFcd21183CH_FLN-like_rpt1cd21227CH_jitterbug-like_rpt1cd21228CH_FLN_rpt1cd21308CH_FLNA_rpt1cd21309CH_FLNB_rpt1cd21310CH_FLNC_rpt1cd21311CH_dFLNA-like_rpt1cd21184CH_FLN-like_rpt2cd21229CH_jitterbug-like_rpt2cd21230CH_FLN_rpt2cd21312CH_FLNA_rpt2cd21313CH_FLNB_rpt2cd21314CH_FLNC_rpt2cd21315CH_dFLNA-like_rpt2cd21185CH_jitterbug-like_rpt3cd21186CH_DMD-like_rpt1cd21231CH_DMD_rpt1cd21232CH_UTRN_rpt1cd21187CH_DMD-like_rpt2cd21233CH_DMD_rpt2cd21234CH_UTRN_rpt2cd21188CH_PLEC-like_rpt1cd21235CH_PLEC_rpt1cd21236CH_DYST_rpt1cd21237CH_MACF1_rpt1cd21189CH_PLEC-like_rpt2cd21238CH_PLEC_rpt2cd21239CH_DYST_rpt2cd21240CH_MACF1_rpt2cd21190CH_SYNE-like_rpt1cd21241CH_SYNE1_rpt1cd21242CH_SYNE2_rpt1cd21191CH_CLMN_rpt1cd21192CH_SYNE-like_rpt2cd21243CH_SYNE1_rpt2cd21244CH_SYNE2_rpt2cd21245CH_CLMN_rpt2cd21193CH_beta_spectrin_rpt1cd21246CH_SPTB-like_rpt1cd21316CH_SPTBN1_rpt1cd21317CH_SPTBN2_rpt1cd21318CH_SPTBN4_rpt1cd21247CH_SPTBN5_rpt1cd21194CH_beta_spectrin_rpt2cd21248CH_SPTB_like_rpt2cd21319CH_SPTB_rpt2cd21320CH_SPTBN1_rpt2cd21321CH_SPTBN2_rpt2cd21322CH_SPTBN4_rpt2cd21249CH_SPTBN5_rpt2cd21199CH_CYTScd21256CH_CYTSAcd21257CH_CYTSBcd21200CH_SMTN-likecd21258CH_SMTNAcd21259CH_SMTNBcd21260CH_SMTNL1cd21261CH_SMTNL2cd21201CH_VAVcd21262CH_VAV1cd21263CH_VAV2cd21264CH_VAV3cd21202CH_PIXcd21265CH_alphaPIXcd21266CH_betaPIXcd21203CH_AtKIN14-likecd21204CH_GAS2-likecd21267CH_GAS2cd21268CH_GAS2L1_2cd21269CH_GAS2L3cd21205CH_LRCHcd21270CH_LRCH1cd21271CH_LRCH2cd21272CH_LRCH3cd21273CH_LRCH4cd21206CH_IQGAPcd21274CH_IQGAP1cd21275CH_IQGAP2cd21276CH_IQGAP3cd21207CH_dMP20-likecd21208CH_LMO7-likecd21277CH_LMO7cd21278CH_LIMCH1cd21209CH_TAGLN-likecd21279CH_TAGLNcd21280CH_TAGLN2cd21281CH_TAGLN3cd21210CH_SCP1-likecd21211CH_CNNcd21282CH_CNN1cd21283CH_CNN2cd21284CH_CNN3cd21212CH_NAV2-likecd21285CH_NAV2cd21286CH_NAV3cd21213CH_DIXDC1cd21214CH_ACTN_rpt1cd21215CH_SpAIN1-like_rpt1cd21216CH_ACTN_rpt2cd21287CH_ACTN1_rpt2cd21288CH_ACTN2_rpt2cd21289CH_ACTN3_rpt2cd21290CH_ACTN4_rpt2cd21291CH_SpAIN1-like_rpt2cd21217CH_PLS_FIM_rpt1cd21292CH_PLS_rpt1cd21323CH_PLS1_rpt1cd21324CH_PLS2_rpt1cd21325CH_PLS3_rpt1cd21293CH_AtFIM_like_rpt1cd21294CH_FIMB_rpt1cd21218CH_PLS_FIM_rpt2cd21295CH_PLS_rpt2cd21326CH_PLS1_rpt2cd21327CH_PLS2_rpt2cd21328CH_PLS3_rpt2cd21296CH_AtFIM_like_rpt2cd21297CH_FIMB_rpt2cd21219CH_PLS_FIM_rpt3cd21298CH_PLS_rpt3cd21329CH_PLS1_rpt3cd21330CH_PLS2_rpt3cd21331CH_PLS3_rpt3cd21299CH_AtFIM_like_rpt3cd21300CH_FIMB_rpt3cd21220CH_PLS_FIM_rpt4cd21301CH_PLS_rpt4cd21332CH_PLS1_rpt4cd21333CH_PLS2_rpt4cd21334CH_PLS3_rpt4cd21302CH_AtFIM_like_rpt4cd21303CH_FIMB_rpt4cd21221CH_PARV_rpt1cd21304CH_PARVA_B_rpt1cd21335CH_PARVA_rpt1cd21336CH_PARVB_rpt1cd21305CH_PARVG_rpt1cd21222CH_PARV_rpt2cd21306CH_PARVA_B_rpt2cd21337CH_PARVA_rpt2cd21338CH_PARVB_rpt2cd21307CH_PARVG_rpt2cd21223CH_ASPM_rpt1cd21224CH_ASPM_rpt2cd21225CH_CTX_rpt1cd21226CH_CTX_rpt2cd22198CH_MICAL_EHBP-likecd21195CH_MICAL2_3-likecd21250CH_MICAL2cd21251CH_MICAL3cd21196CH_MICAL1cd21197CH_MICALLcd21252CH_MICALL1cd21253CH_MICALL2cd21198CH_EHBPcd21254CH_EHBP1cd21255CH_EHBP1L1
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1         #   #                                                     # ##  ## #           
Q9HBI1        88 ELVKVLLDWINDVLVEERIIvKQLEEDLYDGQVLQKLLEKLAGCKLnvaev---tqseiGQKQKLQTVLEAVHDLLrp-- 162 human
Q9HBI0        45 ELQKVLMEWINATLLPEHIVvRSLEEDMFDGLILHHLFQRLAALKLeaedi---altatSQKHKLTVVLEAVNRSLql-- 119 human
TPX48402      50 QLVTTLTAWVNSYIKKDHMVvRDLISDLSDGHLLLAFITRLTNEQIpytv------dgaGEKSQRINVSACVRFCEtl-- 121 Synchytrium end...
ORX43434      28 TLMRSLTAWINQTLQKQHLIvRDIVYDLSDGQILAAFIETLTYENLddil------pgsTEKNKISNINKCIQFAVdkl- 100 Piromyces finnis
TNN12916     351 DLSSSLIEWINTELLDDRILvRNLEDDLFDGQVLQKLIEKLLSIKInhpev---aqteiGQKQRLKIVLDEINAALgis- 426 Schistosoma jap...
PAA77202      80 NLIAVLKDWLNEVLVADRMVvRSLADDLYDGQVLQILLHRLFNRTLsepdv---ihsahGQRQRLESVLAALDELL---- 152 Macrostomum lig...
KXJ18648      98 QLKVVLLEWLNEVLADKRIVvRDVEEDLYDGLILSHLMEKLADIVLqefkev--nqtveVQQAKLSVLLNEINKTIrv-- 173 Exaiptasia pallida
RDD38182      62 ELIECLTDWIHDELSDKHIIvRDILDDIYDGQVLAILTEKLARTKLdvpei---aqsvaSQKERLRVVLDYVHRWLh--- 135 Trichoplax sp. H2
NP_499891    100 QVVDLLIYWLNEELADQRIVvRHLQEDLFDGQIIQKLLEKLEQIRIevpev---sqseeGQRQKLQIVVQTANRILgq-- 174 Caenorhabditis ...
OAF70657      67 NLQNSLLEWINSELIDTRIViKSIYSDLGDGQVLQNLLEVLENLKIklpel---tytkeGQIQKLTVIIQCFDDVLfpn- 142 Intoshia linei
RKP00736      11 KLRLILTSWINAHLAQQHIViRDIVTDLADGQLLGAFLECATGEHLntv-------ssmGQKSKDATMSNVVSFLGthl- 82  Caulochytrium p...
CBY22766      65 ELDACLKQWINECLAGQRIIvKDLEEDLFDGQVLQRLFEHLHYGGQerlekpdivctkqGQLDKLDYVLKMIQDECegfh 144 Oikopleura dioica
XP_009493713  20 RFRRILMSWLNQHLREDRVYvRDIVEDLHDGQLLVLFLEKTLQVAIhsdptg--pvsdrGKRGNLAVVLRFLRERVg--- 94  Fonticula alba
Feature 1                #########    # ## ##  ##  #  
Q9HBI1       163 ------rGWALRWSVDSIhgKNLVAILHLLVSLAMHF 193 human
Q9HBI0       120 ------eEWQAKWSVESIfnKDLLSTLHLLVALAKRF 150 human
TPX48402     122 -----gmQQSGRFSVDGIlgRDIVSVLCLLVDLVHVV 153 Synchytrium endobioticum
ORX43434     101 ----gleRDPQRWTAEGIvkRDISSILAFLVDLSHYA 133 Piromyces finnis
TNN12916     427 -----plRAAQLWPTSAVyeRDLVAILRLLVALVHKF 458 Schistosoma japonicum
PAA77202     153 -------GRRAEWTAEEIygRQLVPVLRLLVAIASAA 182 Macrostomum lignano
KXJ18648     174 ------pQHRAKWTTEKVhsKDTVAILHLLVSLAKHY 204 Exaiptasia pallida
RDD38182     136 ------pESGKNWSVEKVysKNAISILQILVEISKQS 166 Trichoplax sp. H2
NP_499891    175 ------pREQEKWSADLIhqKDFTAIIQLLVLLALHY 205 Caenorhabditis elegans
OAF70657     143 -----nvERVIKWTPYGInnNDSIEILHFLIALYYNY 174 Intoshia linei
RKP00736      83 ----hihEDEARWTASGIraRDISSIFVLLVALTRVL 115 Caulochytrium protostelioides
CBY22766     145 qelfqdeDDERRAYVDCIytKNYHAICYLLVVLTKFY 181 Oikopleura dioica
XP_009493713  95 -------LEMSPDIIDGIlnKDVVSICRLLVAMAHEF 124 Fonticula alba

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap
HHS Vulnerability Disclosure