Conserved Protein Domain Family

cd21182: Tudor_SMN_SPF30-like 
Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins
This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
PSSM-Id: 410549
Aligned: 34 rows
Threshold Bit Score: 51.4834
Created: 20-Feb-2020
Updated: 25-Oct-2021
Aligned Rows:
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide binding site [polypeptide binding site]
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
  • Structure:2LTO; Homo sapiens TDRD3 in complex with DNA-directed RNA polymerase II subunit Rpb1 asymmetrically dimethylated CTD peptide, contacts at 4A
    View structure with Cn3D

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1               #    # #                       #  # #            
OWR53711      90 GEKCLAKWktDGVYYEATIEEvy--------eNNLKVRFdgYLKSEIISilDIKAM 137 Danaus plexippus plexippus
CBY31657      61 GMSVQAPYsdDGKLYEAIVNQide------naGTAKVTFaqYGNSETVLisQLNKF 110 Oikopleura dioica
CBJ33140     188 GLECRALYvgDGTYYDCTIQEvt--------aNGYKIVFpaYGNVEEVPleYLQKK 235 Ectocarpus siliculosus
CCA28165     180 GMRCLARYyvDNQFYECVIAEet--------sLGVSVVFdgYGNTEEVPltYLCQL 227 Albugo laibachii Nc14
KNE63365     134 GDQVAAKWavNGKIYEATISAvstqaaksaddIVYSVVFagYTSVELVRqaDVQAY 189 Allomyces macrogynus ATCC 38327
ORY40227      80 NQTVLAKYk-DGKMYEAVVDSvpsa----aqpTHYTVVFkgYTSKEKVLveNVRDF 130 Rhizoclosmatium globosum
XP_006682675 135 GQIVLARWt-DDQFYEARVVGlntva--tsdnVIYDIVFtgFETVEQVSvdSIKQP 187 Batrachochytrium dendrobatidis JAM81
ORX57686      87 GSVVMAKWsvDKQYYEATILNvi-------spTSYQIVFngYGNEEIVSdnDIKEI 135 Piromyces finnis
XP_018918241  68 GMPVRALYseDCKYYEGVVLKvf--------kDTCLIKYlgYNNKEMVPkkNIWES 115 Bemisia tabaci

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