5V6E,5V6B,5V6H


Conserved Protein Domain Family
GH2_GIPC

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cd21180: GH2_GIPC 
GIPC-homology 2 (GH2) domain found in the GIPC family
The GIPC family includes PDZ domain-containing proteins, GIPC1 (also called GAIP C-terminus-interacting protein, RGS-GAIP-interacting protein, RGS19-interacting protein 1, RGS19IP1, synectin, tax interaction protein 2, or TIP-2), GIPC2, and GIPC3, which may act as scaffold proteins linking heterotrimeric G-proteins to seven-transmembrane-type WNT receptor or to receptor tyrosine kinases. They might play key roles in carcinogenesis and embryogenesis through modulation of growth factor signaling and cell adhesion. GIPCs are proteins with a GIPC homology 1 (GH1) domain, a central PDZ domain and a GH2 domain. This model corresponds to the GH2 domain, which mediates the interaction with myosin VI and is involved in homodimerization in the autoinhibited state.
Statistics
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PSSM-Id: 409666
Aligned: 60 rows
Threshold Bit Score: 81.8211
Created: 2-Dec-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
homodimermyosin VI
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    #  ######                              #              
5V6E_A         8 EEKAIEKVDDLLESYMGIRDTELAATMVELGKDKrNPDELAEALDER-LGDFAFPDEFVFDVWGAI 72  house mouse
5V6B_A       214 EEKAIEKVDDLLESYMGIRDTELAATMVELGKDKrNPDELAEALDER-LGDFAFPDEFVFDVWGAI 278 house mouse
NP_501810    262 QAEMCGKLNELFDQYLGVQDDQLAMRIWETASNCeTLWQLSEAIKQSeLSMFEFPDGLVFDMWGII 327 Caenorhabditis elegans
EEC00805     270 IQAAVDKINALLESYMGINDSELATQIWELGCERpNPHEFVTAIGDSdLDAFGFTEDFLFDIWGAI 335 black-legged tick
CBY21056     216 KRSAIEIIDQMLEDYVGIRDRELSLSIYESGTKSsDSGSFLDTVTSA-YPMFAFTDQFILDVWNII 280 Oikopleura dioica
XP_009024643 226 SSVAVDKINAMLEGFLGISDAELSQTIWELGSKSnNPSEFVTIIRDSdLSMFGFTEVFIFELWGAI 291 Helobdella robusta
XP_015786287 373 STSVIEKINVLLESFMGIHDNELATQIWETGSTHgNPHDFVMAIGDSdLQIFGFNEDLLFDLWGVI 438 two-spotted spider mite
PAA92205     260 ADVAIQAVNRLIEGLLGISDAELAQNIWELGQEIdNPHDFALAVDRD-LGEFAFPDGLVFDFWGAI 324 Macrostomum lignano
PDM62880     251 DATLLKGINVIFENYLGVNDDQLALLVAEMAMASqSFTELGDKVKNSeLAVFQLPDEFIFDIWGVL 316 Pristionchus pacificus
RNA14889     238 VDLAVAKINSLLETFMGIHDSDLAQTIWELGRDYkNPHEFIEAISKSeICDFGFSEDFVFDLWGAI 303 Brachionus plicatilis

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