5UFV,2VTC,2YET,4B5Q,4D7U,4EIR,4EIS,4QI8,5ACF,5FOH,5NLT,5NNS,5O2W,5X6A,6RS6,5NLS


Conserved Protein Domain Family
LPMO_AA9

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cd21175: LPMO_AA9 
lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9)
AA9 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs) involved in the cleavage of cellulose chains with oxidation of carbons C1 and/or C4 and C6. Activities include lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54) and lytic cellulose monooxygenase (C4-dehydrogenating) (EC 1.14.99.56). The family used to be called GH61 because weak endoglucanase activity had been demonstrated in some family members.
Statistics
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PSSM-Id: 410622
Aligned: 178 rows
Threshold Bit Score: 159.297
Created: 22-Jan-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
Cu binding siteputative
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Cu binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H H [EQ] [FY]Click to see conserved feature residue pattern help
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #                                                                               
5UFV_A         1 XGAVTSYNIA-GKDYPGysgfap----tgqdvIQWQWp---dYNPVLSasdpKLRCNGg-tGAALYAEAAPg---dTITA 68  Thermothelomyce...
ELU45255      19 HGYIDKVTIG-GKTFSGpypfsn----knaasPIRKIt---tTFPITSandaNMNCGI---DAAPAAQVAAanpgdKVTF 87  Rhizoctonia sol...
ELU45307      20 HGYIGVLTAN-GKSYKGpvagg-----pkiksPIRQIs---tTSPYKDvngpGMTCGRdakNAALIADVDAg---sKITM 87  Rhizoctonia sol...
CCO27431      20 HGYVDKIVAN-GKTYNGpipge-----tnpksPIRRIk---tIDPYKKpsgsGITCGEgaqLASVVAPITAg---sDLTL 87  Rhizoctonia sol...
XP_006958163  17 HGIVKQVIFD-GVTYDGpypnygeeqefkaqgPIRQVk---nLDPITDiyspDLACGReslPSEYSAEVGAg---aEIEF 89  Wallemia sebi C...
XP_007400275  85 HGSVHKIVID-GKEYDGpavgkg----plsgsPIRAIs---eVDPVKGatnpSLSCGQn--ASLADTTASAnp-gsQLQL 153 Phanerochaete c...
XP_009266448  17 HGVVSYIDVN-GQGFNGpdp---------nqsSQNAPewtsgINPIKDpyssDMFCGPn-sSPNSVATIGAg---sTMTL 82  Wallemia ichthy...
XP_009266847  17 HGTVNRIDVEgGQSFSGpligs-----ndnsgPIWHVs---tSSPVTDlqsnSMFCGVdaiPGQQSPNIGAg---sTLTI 85  Wallemia ichthy...
XP_009268449  16 HGIVKQVILN-DQTHTGpypnygddseikskgPIRQVt---nTKPIKDiyspNLSCGRdsvPSEYSAPVAAg---tDVEF 88  Wallemia ichthy...
RPD72970      21 HGVVISFTAN-GKTYTGepnpdq---ptgaasPIRAVa---nNGPVVDvsdkNMACGAstkVATMDVPVDAg---sVVSV 90  Lentinus tigrin...
Feature 1                      #                                                                 
5UFV_A        69 TWAQWt--------HsQGPILVWMYKCPGDfss--cdgSGAGWFKIDEAGFHgdgttvfldtetpsgwdiaklvggNKSW 138 Thermothelomyce...
ELU45255      88 SWKSGqnkn-vrwgHsIGPIMTYLAQVPAGqtadkfdtRKAKFFKIDQTGQTggagtgw----------vqasikgGKTY 156 Rhizoctonia sol...
ELU45307      88 TWDDHpgd---twnHdLGPLMTYMTKVPEGqtadkfnpANAQWFKVAQDGLKsngkwv------------qadlmsGGAH 152 Rhizoctonia sol...
CCO27431      88 SWVAHpgq---pwpHeMGPLITWMAKVPTGqtadkfdaSKGDFFKVHQEGQEgkkwyl------------erlmklGTTM 152 Rhizoctonia sol...
XP_006958163  90 VWNGGddgy--pwpHqVGPLLTYMGNCYDDcnn--vdpTTVDFFKISEQDMRedgqwe------------qaslvdFATA 153 Wallemia sebi C...
XP_007400275 154 FWINGqgg---pwpHnAGPIINYMASCGGNdcsq-fdaSKAEWFKIEQSGVQsdgtwe------------qaalmqGQPF 217 Phanerochaete c...
XP_009266448  83 WWEETaqq---qwpHnTGPIITYMAQCTTDcan--mnaDSAKWFKIDQVGFEngqwkq-------------aslmnGGGY 144 Wallemia ichthy...
XP_009266847  86 HWGQGyadsgdqwpHnTGPIMTYMAKCNGDcsn--adsASSNFFKISELGIEngewvq-------------aqlknGQPY 150 Wallemia ichthy...
XP_009268449  89 IWNGGedgi--pwpHsTGPIITYMGNCNGDckn--vdpTTIDFFKISEDDKRpdgmwe------------qatlknFNTV 152 Wallemia ichthy...
RPD72970      91 QWTKPw-------pHqWGPIITYLASCGEPcski-tdpTNLTWFKIDQLGASntsdttwv---------qgtllfkSQPV 153 Lentinus tigrin...
Feature 1                                       # #                                              
5UFV_A       139 SSKIPDGlaPGNYLVRHELIALHQa---nNPQFYPECAQIKVTGsgta--epaaSYKAAIPGYCQQSDPNISFNINdhsl 213 Thermothelomyce...
ELU45255     157 TTTLPNDlpAGDYIIRHELIALHFaqkkdGAQFYPGCVQIRVGGgsnap-kaisAQTVSFPGGYTENDKSLFVPNLfkg- 234 Rhizoctonia sol...
ELU45307     153 SVTIPKNipSGQYLMRSEIIALHLadkrgGVEFYGNCIQFNVKNgaggsnfldgVTTAKFPGTYSLDDKGIHINVFnrl- 231 Rhizoctonia sol...
CCO27431     153 SIPIPKEleDGDYIMRHEIIALHLadnkgGAEFYSSCFQLKVTGgtgta-kttaSETVRFPGAYDASNPGIYVPNVfnn- 230 Rhizoctonia sol...
XP_006958163 154 KSKIPGNiqPGNYIIRHEIIALHNanevgGCEFYPSCTNVYVNSdgd----svpGDTVRFPGGYDPEEAGIYTPELynqq 229 Wallemia sebi C...
XP_007400275 218 SLTLPENlkPGGYLLRNEIISLQLamssgGYESYPSCSQLLIGGngn----gvpDETVQFPGAYSDNDPGLLVNIYpla- 292 Phanerochaete c...
XP_009266448 145 QVTIPEDlaAGDYLMRTEIISLHAs----RPQYYPRCVSWTITGdgsn--tysdDATATFPGTYSWSDAGLASSGSdiyn 218 Wallemia ichthy...
XP_009266847 151 SVQIPNDvqPGNYLIRTEIVALHS-----GVESYPSCSQFTVTGdgsn---syaSATAKFPGAYLASDPGLQIAGGsvyn 222 Wallemia ichthy...
XP_009268449 153 KATVPWDiaSGNYMIRHEIIALHEanmvgGCEFYPSCINVQVQGggd----aypSDTVKFPGGYNEQDPGIYLPNMydsq 228 Wallemia ichthy...
RPD72970     154 QLTIPDKlkPGYYMIRHEIIALHNamnkgGAEFYPQCIQIEVKGntgnl-vpssGDMVHFPGEYQANDPGILVDVFtpks 232 Lentinus tigrin...
Feature 1                           
5UFV_A       214 -------pqeYKIPGPPVF 225 Thermothelomyces thermophilus ATCC 42464
ELU45255     235 -------nfvYPFPGPQVV 246 Rhizoctonia solani AG-1 IA
ELU45307     232 --------ksYPFPGPAIA 242 Rhizoctonia solani AG-1 IA
CCO27431     231 -------gfkYKFPGPAVA 242 Rhizoctonia solani AG-1 IB
XP_006958163 230 e-----gitgYQQPGPGIY 243 Wallemia sebi CBS 633.66
XP_007400275 293 --------gpYVFPGGPIS 303 Phanerochaete carnosa HHB-10118-sp
XP_009266448 219 v----qsdsaYQFPGPELI 233 Wallemia ichthyophaga EXF-994
XP_009266847 223 i----qssveYQFPGPAPV 237 Wallemia ichthyophaga EXF-994
XP_009268449 229 q-----gitdYQQPGPALY 242 Wallemia ichthyophaga EXF-994
RPD72970     233 neptynvkkdYQFPGGPIP 251 Lentinus tigrinus ALCF2SS1-7

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