2RHB,2GTH,2GTI,2H85,2OZK,4RS4,4S1T,5YVD,6WLC


Conserved Protein Domain Family
NTD_alpha_betaCoV_Nsp15-like
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cd21171: NTD_alpha_betaCoV_Nsp15-like 
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N-terminal domain of alpha- and beta-coronavirus Nonstructural protein 15 (Nsp15), and related proteins
Coronavirus (CoV) Nsp15 is a nidovirus endoribonuclease (NendoU). NendoUs are uridylate-specific endoribonucleases, which release a cleavage product containing a 2',3'-cyclic phosphate at the 3' terminal end. NendoUs include CoV Nsp15 and arterivirus Nsp11, both of which may participate in the viral replication process and in the evasion of the host immune system. This small NTD structure, present in coronavirus Nsp15, is missing in Nsp11. CoV Nsp15 has an N-terminal domain, a middle (M) domain, and a C-terminal catalytic (NendoU) domain. Nsp15 from Severe Acute Respiratory Syndrome (SARS)-CoV, human CoV229E (HCoV229E), and Murine Hepatitis Virus (MHV) form a functional hexamer. Residues in this N-terminal domain are important for hexamer (dimer of trimers) formation.
Links
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Statistics
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PSSM-Id: 439163
Aligned: 123 rows
Threshold Bit Score: 110.735
Created: 14-Feb-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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trimerhexamer
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:
  • Comment:functions as a hexamer (dimer of trimers)
  • Structure:2RHB: SARS-coronavirus Nsp15 trimer interface; contacts at 4A
  • Structure:4RS4: human Coronavirus 229E (HCoV229E) Nsp15 trimer interface, contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 ######            #### #  # ######  ####            #
2RHB_A          8 SLENVAYNVVNKGHFDGHAGEAPVSIINNAVYTKVDGIDVEIFENKTTLPVNVAFELWAKR 68   Severe acute respiratory syndrom...
YP_009072438 6596 GLENVAYNVVNKGHFDGTQGEIPTAVIGDKVFVKREGVDVCVFTNNTTLPTNVAFELYAKR 6656 Bat Hp-betacoronavirus/Zhejiang2013
ATP66731     6806 SLENVVYNLVKTGHYTGQAGEQPCAIINDKVVAKIDQEDVIVFTNNTTYPTNIAVELFAKR 6866 Rodent coronavirus
ABP87986     6464 SLENVVYNLVKTGYYTGQAGEMPCAIINDKVVAKIEQEDVVVFTNNTTYPTNIAVELFAKR 6524 Equine coronavirus
AYR18604     6462 SLENVVYNLVKTGAFTGEAGEMPCAIRNDKVFAKIEQEDVLVFKNNTTFPTNVAVELFAKR 6522 Betacoronavirus sp.
AFE48810     6478 SLENVVYNLVKTGHYTGQTGEMPCAIINDKVVAKIEQEDVVIFTNNTTYPTNIAVELFAKR 6538 Rabbit coronavirus HKU14
AID16629     6402 SLENVVYNLVKTGAFTGEAGEVPCAIRNDKVFAKIEQEDVIVFKNNTTFPTNVAVELFAKR 6462 Longquan Aa mouse coronavirus
AYR18613     6431 SLENVVYNLVKTGAFTGEAGEMPCAIRNDKVFAKIEQEDVVVFKNNTPFPTNIAVELFAKR 6491 Betacoronavirus sp.
P0C6X3       6480 SLENVIYNLVNAGHYDGRIGELPCAIMNDKVVVKINNVDTVIFKNNTSLPTNIAVELFTKR 6540 Human coronavirus HKU1 (isolate N2)
P0C6X4       6460 SLENVIYNLVNVGHYDGRTGELPCAIMNDKVVVKINNVDTVIFKNNTSFPTNIAVELFTKR 6520 Human coronavirus HKU1 (isolate N5)

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