5YVD,2RHB,4RS4


Conserved Protein Domain Family
NTD_CoV_Nsp15-like
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cd21170: NTD_CoV_Nsp15-like 
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N-terminal domain of coronavirus Nonstructural protein 15 (Nsp15) and related proteins
Coronavirus (CoV) Nsp15 is a nidovirus endoribonuclease (NendoU). NendoUs are uridylate-specific endoribonucleases, which release a cleavage product containing a 2',3'-cyclic phosphate at the 3' terminal end. NendoUs include CoV Nsp15 and arterivirus Nsp11, both of which may participate in the viral replication process and in the evasion of the host immune system. This NTD structure (approximately 60 residues) present in CoV Nsp15, is missing in Nsp11. CoV Nsp15 has an N-terminal domain, a middle (M) domain, and a C-terminal catalytic (NendoU) domain. Nsp15 from Severe Acute Respiratory Syndrome (SARS)-CoV, human CoV 229E (HCoV229E), and Murine Hepatitis Virus (MHV) form a functional hexamer. Oligomerization of Porcine DeltaCoronavirus (PDCoV) Nsp15 differs from the Nsp15 of these alpha- and beta-coronavirus; it has been shown to exist as dimers and monomers in solution, and to function as a dimer. Nsp15 from Turkey CoV (TCoV), a gammaCoV, has been reported to be a homohexamer.
Links
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Statistics
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PSSM-Id: 439162
Aligned: 9 rows
Threshold Bit Score: 88.2148
Created: 13-Oct-2021
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative trimerputative
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:putative trimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the structures of SARS-CoV (a betaCoV) and human CoV 229E (an alphaCoV) Nsp15 that function as hexamers (dimer of trimers)
  • Comment:Not all coronavirus Nsp15 form hexamers; Porcine DeltaCoronavirus (PDCoV) Nsp15 has been shown to exist as dimers and monomers in solution.
  • Structure:2RHB: SARS-CoV Nsp15 trimer interface; contacts at 4A
  • Structure:4RS4: human Coronavirus 229E (HCoV229E) Nsp15 trimer interface, contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                ### ##              #### #  # ######  ####            #
5YVD_A          2 LENIAFNVVKqGHFIGV--EGELPVAVVNDKIFTKSGVNDICMFENKTTLPTNIAFELYAKR 61   Middle East respiratory syndrom...
2RHB_A          9 LENVAYNVVNkGHFDGH--AGEAPVSIINNAVYTKVDGIDVEIFENKTTLPVNVAFELWAKR 68   Severe acute respiratory syndro...
4RS4_A          3 LENIAFNVVNkGSFVSA--DGELPVAISGDKVFVRDGNTDNLVFVNKTSLPTNIAFELFAKR 62   Human coronavirus 229E
AKC54434     5663 LENLAYNCYYkNCNAHV--DGQLDVVINNNAVYAKVDNNLVKLFDNRTNLPVSVAFEHYTNR 5722 Porcine deltacoronavirus
AVM87573     4291 LEYVAASVLLyNQYREVsgIVEKNVIVNGDNIFVDDNGSNRLLFTNQSTLPANVAFMLWAQR 4352 Guangdong chinese water skink c...
YP_005352870 5604 LENLAYNVYYkNHNANV--RGELDVVISNNVVSAKVDGRIIKLFENTTILPVSVAFEHYTNR 5663 Wigeon coronavirus HKU20
AWR88313      283 LENLAYNCYYkNHNVKI--KGELDVIITNNVVSVSVDGVIQKIFENYTILPVSVAFEHYTNR 342  Deltacoronavirus sp.
AHB63507     6004 LDQLVANVVKrDHFDDV--KDDVPYVITGDKVFYRKGLQDVLIFENKTSMATSIAFEYYARR 6063 Bottlenose dolphin coronavirus ...
P0C6Y2       5991 IDNIAYNMYKgGHYDAI--AGEMPTVITGDKVFVIDQGVEKAVFVNQTTLPTSVAFELYAKR 6050 Avian infectious bronchitis vir...

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