PUA RNA-binding domain of MJ1432, TA1423, PH0734, and similar proteins
The RNA-binding PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was detected in a number of proteins involved in RNA metabolism. Members of this mostly archaeal family have not been characterized functionally; they may bind to RNA. This family includes Pyrococcus horikoshii PH0734 where the N-terminal domain may modulate the binding target of the C-terminal PUA domain using its characteristic electropositive surface.
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
Comment:many PUA domains have been shown to bind RNA, and although detailed interactions vary, they all seem to share a common surface patch that is associated with binding
Comment:by similarity to other members of this family
Jiyao W et al.(2023). "The conserved domain database in 2023.",