5YVD,2C1W,7K1L,7K1O


Conserved Protein Domain Family
NendoU_XendoU-like
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cd21144: NendoU_XendoU-like 
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Nidoviral uridylate-specific endoribonuclease (NendoU) domain of coronavirus Nonstructural protein 15 (Nsp15), arterivirus Nsp11, torovirus endoribonuclease, Xenopus laevis endoribonuclease XendoU, and related proteins
Nidovirus endoribonucleases (NendoUs) and eukaryotic Xenopus laevis-like endoribonucleases (XendoUs) are uridylate-specific endoribonucleases which release a cleavage product containing a 2',3'-cyclic phosphate at the 3' terminal end. NendoUs include Nsp15 from coronaviruses and Nsp11 from arteriviruses, both of which may participate in the viral replication process and in the evasion of the host immune system. XendoU is involved in the processing of intron-encoded box C/D U16 small, nucleolar RNA. Except for turkey coronavirus (TCoV) Nsp15, Mn2+ is generally essential for the catalytic activity of coronavirus Nsp15. Mn2+ is dispensable, and to some extent inhibits the activity of arterivirus (Porcine Reproductive and Respiratory Syndrome virus) PRRSV Nsp11. XendoU also requires Mn2+. Coronavirus Nsp15 from Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), human Coronavirus 229E (HCoV229E), and murine hepatitis virus (MHV) forms a functional hexamer while Porcine DeltaCoronavirus (PDCoV) Nsp15 has been shown to exist as a dimer and a monomer in solution. Nsp11 from the arterivirus PRRSV is a dimer.
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Statistics
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PSSM-Id: 439156
Aligned: 4 rows
Threshold Bit Score: 155.081
Created: 13-Oct-2021
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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catalytic siteputative active
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: catalytic site [active site], 3 residue positions
Conserved feature residue pattern:H H KClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #               #                                               #            
5YVD_A    228 AFEHVVYGDFsh-tTLGGLHLLIGlykrqqeghii--------meemlkgsstiHNYFITEtntaAFKAvCSVID-LKLD 297 Middle East respir...
2C1W_A    159 GFEHVFVGESkrgqEMMGLHNWVQfylqekrknidykgyvarqnksrpdeddqvLNLQFNWk--eMVKPvGSSFIgVSPE 236 African clawed frog
7K1L_A    255 AFEHIVYGDFsh-sQLGGLHLLIGlakrfkespfe--------ledfipmdstvKNYFITDaqtgSSKCvCSVID-LLLD 324 Severe acute respi...
7K1O_A    255 AFEHIVYGDFsh-sQLGGLHLLIGlakrfkespfe--------ledfipmdstvKNYFITDaqtgSSKCvCSVID-LLLD 324 Severe acute respi...

Feature 1                                                  
5YVD_A    298 DFVMILKsqd--lgVVSKVVKVPidltMIEFMLWCkdgqvQTFYP 340 Middle East respiratory syndrome-related coronavirus
2C1W_A    237 FEFALYTivflasqEKMSREVVRleeyELQIVVNRhgryiGTAYP 281 African clawed frog
7K1L_A    325 DFVEIIKsqd--lsVVSKVVKVTidytEISFMLWCkdghvETFYP 367 Severe acute respiratory syndrome coronavirus 2
7K1O_A    325 DFVEIIKsqd--lsVVSKVVKVTidytEISFMLWCkdghvETFYP 367 Severe acute respiratory syndrome coronavirus 2

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