5ZKY,5ZL4,5ZKW,5ZKU,5ZKS,5ZL5,2INU


Conserved Protein Domain Family
IFTase
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cd21111: IFTase 
inulin fructotransferase
Inulin fructotransferase (IFTase; EC 4.2.2.17 and EC 4.2.2.18), a member of the glycoside hydrolase family 91, catalyzes depolymerization of beta-2,1-fructans inulin by successively removing the terminal difructosaccharide units as cyclic anhydrides via intramolecular fructosyl transfer. As a result, IFTase produces DFA-I (alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,1'-dianhydride) and DFA-III (alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride).
Links
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Statistics
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PSSM-Id: 411049
Aligned: 40 rows
Threshold Bit Score: 227.602
Created: 23-Dec-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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trimerchemical
Conserved site includes 85 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:
  • Structure:2INU; The trimer interface of Bacillus inulin fructotransferase, contacts at 4A
  • Comment:Trimerization is a prerequisite for catalytic activity, and the active site is located at the monomer-monomer interface.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ###   #                                           ##    ### ##   ## #          
5ZKY_A         3 SNNRYDVTEW-------PAGNPAKDi--------gEVINSIIADIKARQGAADvddgGKPGAVIYLPPgDYHLRTQVLID 67  Pseudarthrobact...
2INU_A        11 SPNTYDVTTWrik--ahPEVTAQSDi--------gAVINDIIADIKQRQTSPD----ARPGAAIIIPPgDYDLHTQVVVD 76  Bacillus sp. snu-7
WP_046876897  10 YIKSYDVTTFvs----pSNTSPYEDi--------gKIMSEIQDDIILQQQTNQddkgLRPGATIFIPAgRYRLQTTFVIT 77  Klebsiella mich...
TVV06238     421 LPVWSEDIAWk-----sDFANYYNKseids-kfngIVLNLIDFGAKAEDSNFDn---AIAFNKAIQSLpATGGIIYIPNG 491 Lactobacillus j...
SDZ65341      39 AVATIPLLPHsv---sqYLGIANTT----------GYYNIMDYGAQSDRPGFDn---AKVINEIIQDMgDNGGTIYIPVG 102 Bacillus casein...
WP_117899243   5 LNHIFTVGLWv-----lAASACNSDd--------tYALCGECADQKIINVTQY----GLASDGSTDCSdLINKLIKDMPA 67  Bacteroides ste...
WP_098996758  16 RNFILGLFVWll---tfLSGFPFKVkgvsaltpqtMTLNPVDYGAKLNDPTFRr--nAIIINDLINTMpPSGGVIELPAG 90  Bacillus sp. AF...
WP_136359209  21 GLSVFFLTFLsgfpfkaTKVSAANE----------TIYYPVDYGAQLNNPNFDn---APIINNLINNMpPSGGVIELPAG 87  Bacillus sp. DS...
WP_046514230  21 GLSVFFLTFLsgfpfkaTKVSAANE----------TIYYPVDYGAQLNNPNFDn---APIINNLINNMpPSGGVIELPAG 87  Bacillus sp. SA...
ALJ46467       4 MLGTSCSNDD-------TYTLCDECn--------gQKIIDITQFGLPTDGATDc---ADLINAIIADLpPEGGTILIPEG 65  Bacteroides ovatus

Feature 1         ## #   # ####                    #######                           ###        #
5ZKY_A        68 ISFLRIEGSGHGFTSSSIRFNVpeee----wpdlHELWPGGSRVIVDLPAggagd---saagAAFLVAREGs----pRIS 136 Pseudarthrobact...
2INU_A        77 VSYLTIAGFGHGFFSRSILDNSnpt-------gwQNLQPGASHIRVLTSPsa---------pQAFLVKRAGd----pRLS 136 Bacillus sp. snu-7
WP_046876897  78 INYLVIQGAGHGWMSQASRDAPdtds-----sgwLETAPGASFIELDTSSt----------lTAIRIERDDfat-tgRIS 141 Klebsiella mich...
TVV06238     492 NFFLKSTVTIDRSYVHIMGFNSglrsgidpsdgiTQSGGGGAKITVQNSI------------SAFKIQNTHnd---kRLS 556 Lactobacillus j...
SDZ65341     103 NFYIQSSIEIDRSYISIIGDNSglrsgvdgstntTQSGGGGAKLIVEPGV------------TAVQILDEEns---eRIS 167 Bacillus casein...
WP_117899243  68 EGGVLFFPEGTYRLDSPILLTRnfv-------tlKGEENGNSASIQDKKAkllvnnmecaiqFAPIADVDGhr---nRIS 137 Bacteroides ste...
WP_098996758  91 EMWIYDKIIINRSYVTIRGVNAgtrs-----hvdAEEPPGPDQPALDHPGg-----------GSKLVLGDGctigiiSEK 154 Bacillus sp. AF...
WP_136359209  88 EMWIHSPIKINRSYVTIRGVNAgtrs-----nidPEEQTGLTHPGGGSKLv-----------LGNNCQTAIv-----SER 146 Bacillus sp. DS...
WP_046514230  88 EMWIHSPIKINRSYVTIRGVNAgtrs-----nidPEEQTGLTHPGGGSKLv-----------LGNNCQTAIv-----SER 146 Bacillus sp. SA...
ALJ46467      66 TFRLDSPIQLTRNFVTLKGVNDea--------vtTAADTRESRLVLGNAEya--------lhVAPVADIDGrk---nRIS 126 Bacteroides ovatus

Feature 1        # # ##                                  ## #                   ### ####         
5ZKY_A       137 SVEFSNFCIDGlhftadgsgrhpentYANGKTGIHVASaNDSFRVTDMGFVYLENALTIHkaDALSIHHNFIAECgSCIE 216 Pseudarthrobact...
2INU_A       137 GIVFRDFCLDGvgftp------gknsYHNGKTGIEVASdNDSFHITGXGFVYLEHALIVRgaDALRVNDNXIAECgNCVE 210 Bacillus sp. snu-7
WP_046876897 142 GVELRDFCIGLvvat--------npyNTSGTKGIDIASdSDSLRIEGMGFSLLEEAMVIRnaDSISITNNFIGECaNCIT 213 Klebsiella mich...
TVV06238     557 GITFSGFDLKG---------------DTNGGIGIEGVSnTDRVVIDNMTINNIGIGVKLNgaDAPKISNSWIAETkSSIQ 621 Lactobacillus j...
SDZ65341     168 GVSFKSFQIRG---------------QGNNGIGIEAVQdTDRIVIDDLVINNVGIGVQLHgaDAPSIRNSWIAETkFSII 232 Bacillus casein...
WP_117899243 138 GVEIENLLITGk-------------eNERQGVGIHVKHdNDRIRLTNLTIENFETGIQTNgaDAMVITNCRVSKVnNGLV 204 Bacteroides ste...
WP_098996758 155 RDGAPRVSSIQlen----------flIQGRGTDNGQIAvNIEQDNDAVRIIGVSTIAVGMglRLVGADACTVRGC-WISE 223 Bacillus sp. AF...
WP_136359209 147 RVGAPRVSSIQles----------flIQGRGTDKGQIAvNIDQDNDAVRIIGVSTINVDTglRLNGADACTVRGC-WISE 215 Bacillus sp. DS...
WP_046514230 147 RVGAPRVSSIQles----------flIQGRGTDKGQIAvNIEQDNDAVRIIGVSTINVDTglRLNGADACTVRGC-WISE 215 Bacillus sp. SA...
ALJ46467     127 GVEVNGLTLVGk--------------GDHQGTGIYVEHdNDRLHFFNIKMENMYQGIKLQgcDAITLARIDATDVvNGID 192 Bacteroides ovatus

Feature 1                #  ###                 # #  ###               ##  ## #                ##
5ZKY_A       217 LRGwgqasKITDNLVGA-GPRGHSIYAENHgGLLVTANNVFPRGAssVHFKGVTRSSVTNNRLHAFYPGMVRLEENssEN 295 Pseudarthrobact...
2INU_A       211 LTGagqatIVSGNHXGA-GPDGVTLLAENHeGLLVTGNNLFPRGRslIEFTGCNRCSVTSNRLQGFYPGXLRLLNGckEN 289 Bacillus sp. snu-7
WP_046876897 214 MTSssivaKITNNFFGN-SPGGYSISIENGdRHQITGNTFFWNPQ--IVLLNTHHTNISANKFQGSWPGTIVMLSPcdEN 290 Klebsiella mich...
TVV06238     622 LIGasqqaEIKNNSLGA-QPQGVTILLENAdRYNITGNNIYPDGSsaIRLLNPVHGTIAGNTISAFYTGIIEMLPSg-ST 699 Lactobacillus j...
SDZ65341     233 LNGasqqaSIVNNSLGA-QPDGVTIELENAkWFNISGNNIYPDGSsnIRLYNPIHGTISSNTISARYNGMIELLPNefGE 311 Bacillus casein...
WP_117899243 205 MLGgi-qnTISDSSFSS-GESGTSCNLSNEtNLLFAHNQLLQGGDcaLQLNACNRINVTENTLESAYVGVMEVNGS--HN 280 Bacteroides ste...
WP_098996758 224 VHDglhslGSSQQLLVAnNYLGAQPGGRSVyLENPEWANIVGNNI--YPDGHVCLEAKGAQNCTFTGNNIQSYYTGavII 301 Bacillus sp. AF...
WP_136359209 216 VRNgllsvGASQQLLVAnNYFGTQPLGKSVfLENPNWANIVGNNI--YPDGHVCLEAIGANDCTFTGNNIQSYYTGavII 293 Bacillus sp. DS...
WP_046514230 216 VRNgllsvGASQQLLVAnNYFGTQPLGKSVfLENPNWANIVGNNI--YPDGHVCLEAIGANDCTFTGNNIQSYYTGavII 293 Bacillus sp. SA...
ALJ46467     193 MNGgi-qnMVTNSVFGS-TQGGVTARISGEsNLIFSHNKLTANDDrcANFIGCNRVNISDNEFTGNKMTFFDISGQ--NN 268 Bacteroides ovatus

Feature 1        # #### #                               # # #              # #                   
5ZKY_A       296 LVATNHFLRDHEPwtpffGVDNGLDDLt---gLLSISGNNNSVIg------------NHFSEVVDANEIRPeg------- 353 Pseudarthrobact...
2INU_A       290 LITANHIRRTNEGyppfiGRGNGLDDLy---gVVHIAGDNNLISd------------NLFAYNVPPANIAPag------- 347 Bacillus sp. snu-7
WP_046876897 291 LISSNMFIRVDTEtasadVGGTIYDDLm---gIVHISGNNNSITs------------NMFSITFSDVSNIRpag------ 349 Klebsiella mich...
TVV06238     700 YGNSNVISGNVIAieawkNNPIGRDNKw---gIIHIEGYNNLIAg------------NNILSNGSPQNTTGvlimkgdsn 764 Lactobacillus j...
SDZ65341     312 YGNGNIINGNVISl---iEYRNHPSDKdiewgILHVEAYNTNINg------------NQIIADGMPEGYTGil------- 369 Bacillus casein...
WP_117899243 281 QFSKNLFKLVLNDn----DQLRGKEADy---gAIRLKGDANHFVsnqiqcewassiqNPITVVVPEGRNNRfa------- 346 Bacteroides ste...
WP_098996758 302 NGDGNLFSGKVQAr---rDLGNWKQDP-----IGRDGLYGLIHVdg---------ndNHITASSINSDQPEn-------- 356 Bacillus sp. AF...
WP_136359209 294 KGNGNLFSGKVQAlr--dGAGNWKSDP-----IGRDGFYGLIHVng---------ndNHITASTINSAQPEn-------- 349 Bacillus sp. DS...
WP_046514230 294 KGNGNLFSGKVQAlr--dGAGNWKSDP-----IGRDGLYGLIHVng---------ndNHITASTINSAQPEn-------- 349 Bacillus sp. SA...
ALJ46467     269 LISDNLFTVNRSE-----NQLNGKEADy---gVIHVKGEYNHFTsntiqvawsdnieNPVTVNAAEGENNRfa------- 333 Bacteroides ovatus

Feature 1                     # # ## #                                     # ##                  
5ZKY_A       354 -atPVIIRLTAGTGNFVSTNHvvs------------------nvdTQHVLVDPGSARNTILDs-----------gSDTQV 403 Pseudarthrobact...
2INU_A       348 -aqPTQILIAGGDANVVALNHvvs------------------dvaSQHVVLDASTTHSKVLDs-----------gTASQI 397 Bacillus sp. snu-7
WP_046876897 350 -adPVAILVADDSDNTLLSSNhlay----------------sdniSVKLVLDSSSRNSRVFQtalyeeflpsagaTYIFL 412 Klebsiella mich...
TVV06238     765 kiaSNVINIPNTDSNVVCNGGannnsvifs------tkgnsfqngLNSSNINVDVDSYTALQlrc--------etLETQL 830 Lactobacillus j...
SDZ65341     370 -veYGENNRISNNSIGVTNPS------------------------NAKIVVNDTATSTIVTDsi----------yENEFL 414 Bacillus casein...
WP_117899243 347 --dCSIDNQTSACVFYVSEDTevlncvedetki-nykqeeknytkAAYIVVAEDADMIEDDDe-----------kASYNW 412 Bacteroides ste...
WP_098996758 357 ---DTRILIMGGNGNWVTNTKi----------------------yGRSSIRKVVVNGSCVDTri---------vhSASEL 402 Bacillus sp. AF...
WP_136359209 350 ---NTRILIMGGNGNWVTNTKi----------------------yGISSNRKVVVNGSCVDTri---------vhSASSL 395 Bacillus sp. DS...
WP_046514230 350 ---NTRILIMGGNGNWVTNTKi----------------------yGISSNRKVVVNGSCLDTri---------vhSASSL 395 Bacillus sp. SA...
ALJ46467     334 --sFTIENTSSNQVFYISESSevidcgvteenikvkpseaqdltnAAYVITYDTPEEIEDDDe-----------kASYAW 400 Bacteroides ovatus

Feature 1               # #  #
5ZKY_A       404 VADRAVNAIRATP 416 Pseudarthrobacter chlorophenolicus A6
2INU_A       398 TSYSSDTAIRPTP 410 Bacillus sp. snu-7
WP_046876897 413 GSDGKDMNGNVII 425 Klebsiella michiganensis
TVV06238     831 STLQYQMSNLLSV 843 Lactobacillus jensenii
SDZ65341     415 NYGNDSNVNVPLP 427 Bacillus caseinilyticus
WP_117899243 413 FKKEFVNGVVLTP 425 Bacteroides stercoris
WP_098996758 403 EVDRADSNTTLVW 415 Bacillus sp. AFS037270
WP_136359209 396 EVDKASSNTTIVW 408 Bacillus sp. DSL-17
WP_046514230 396 EVDKANSNTTIVW 408 Bacillus sp. SA1-12
ALJ46467     401 FKKQFVNGKVITS 413 Bacteroides ovatus

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