Conserved Protein Domain Family
Arl6IP1_RETR3-like

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cd21102: Arl6IP1_RETR3-like 
ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and similar proteins
This family contains ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1) and the N-terminal reticulon-homology domain (RHD) of Reticulophagy regulators 1-3. Arl6IP1 is an endoplasmic reticulum (ER) protein that has an important role in cell conduction and material transport. Arl6IP1, a tetraspan membrane protein, is an anti-apoptotic protein specific to multicellular organisms, and is a potential player in shaping the ER tubules in mammalian cells. In Drosophila, knockdown of the Arl6IP1 gene leads to progressive motor deficit. An Arl6IP1 variant has also been associated with hereditary spastic paraplegia (HSP), motor and sensory polyneuropathy, and acromutilation. Reticulophagy regulator 1 (RETREG1/FAM134B) is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. RETREG2/FAM134A and RETREG3/FAM134C has been shown to interact with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. Arl6IP1 shows some sequence similarity to the RHD of reticulophagy regulators, which may function in inducing membrane curvature.
Statistics
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PSSM-Id: 411696
Aligned: 6 rows
Threshold Bit Score: 197.277
Created: 23-Dec-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q15041        34 DKVLRWERAWFPPAIMGVVSLVFLIIYYLDPSVLSGVSCFVMFLCLADYLVPil--------------apRIFGSNKWTT 99  Homo sapiens
Q86VR2        57 QAALVWERPARSALWCLGLNAAFWFFALTSLRLVFLLAFGLMIIVCIDQWKNkiw------------peiKVPRPDALDN 124 human
Q8NC44        71 QRLLVWEKPLHSLVTAAALNGLFWLLSSSSLRPFFLLSVSLLAYFLLDLWQPrflp----------dvsaSSPEEPHSDS 140 human
Q9H6L5        84 DELLSWKRPLRSLLGFVAANLLFWFLALTPWRVYHLISVMILGRVIMQIIKDmvl------------srtRGAQLWRSLS 151 human
XP_002154234  41 ENILFWKAPTVSLAIYLVFTGLFWKFISYRLQKISLLLIILSSPCLIDDVRIiiwn----------nleqRGAAVIKERR 110 Hydra vulgaris
XP_019850792  38 QEAVLLRKIFLSACLYAAIHFVFWNLYYLNDNCFSFLGRLLFWILLVDGFWViatrdktvpgqessglrlRLRRKREQTS 117 Amphimedon quee...
Q15041       100 EQ-QQRFHEi-----------------CSNLVKTRRRAVGWWKRLFTLKEEKPkmYFMTMIVSLAAVAWVGQqVHNLLLT 161 Homo sapiens
Q86VR2       125 ES-WGFVHPrlls----------vpelCHHVAEVWVSGTIFIRNVLLFKKQNPgkFCLLSCGILTFLAVLGRyVPGLLLS 193 human
Q8NC44       141 EGaGSGARPhlls----------vpelCRYLAESWLTFQIHLQELLQYKRQNPaqFCVRVCSGCAVLAVLGHyVPGIMIS 210 human
Q9H6L5       152 ES-WEVINSkpde----------rprlSHCIAESWMNFSIFLQEMSLFKQQSPgkFCLLVCSVCTFFTILGSyIPGVILS 220 human
XP_002154234 111 RV-GFEFDDm-----------------CNSIAQIWISAENSMLYLLQLKEQELtkFCLHIGCYISVLVIFFAyIPVAEIM 172 Hydra vulgaris
XP_019850792 118 YV-SFEKAAmkntkklevgevaefevvCLWIAISLMWIDNVQLAMRHWNREQPymLTVLLLVGGLVTCLLGYfIDFVLLV 196 Amphimedon quee...
Q15041       162 YLIVTSLLLLPGLNQHGIILKyigm-----------------akrEINKLLKQKEK 200 Homo sapiens
Q86VR2       194 YLMLVTVMMWPLAVYHRLWDRay--------------------vrLKPALQRLDFS 229 human
Q8NC44       211 YIVLLSILLWPLVVYHELIQRmy--------------------trLEPLLMQLDYS 246 human
Q9H6L5       221 YLLLLCAFLCPLFKCNDIGQKiy--------------------skIKSVLLKLDFG 256 human
XP_002154234 173 FGFGTIVYFFPIINYLGLLDFllnk----------------iarfVHPIYLHLSNS 212 Hydra vulgaris
XP_019850792 197 YIIVMLLLLWPVLSYYSVISSltaaintnypiftqkvqnyyeimkRHFRRLPDDEF 252 Amphimedon queenslandica
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