5AJ1


Conserved Protein Domain Family
WH_NTD_SMARCB1

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cd21086: WH_NTD_SMARCB1 
N-terminal winged helix DNA-binding domain found in SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) and similar proteins
SMARCB1, also termed BRG1-associated factor 47 (BAF47), or integrase interactor 1 protein (INI1), or SNF5, or SNF5L1, is a core component of the BAF (hSWI/SNF) complex, an ATP-dependent chromatin-remodeling complex that plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The model corresponds to the N-terminal winged helix DNA binding domain of SMARCB1, which is structurally related to the SKI/SNO/DAC domain that is found in a number of metazoan chromatin-associated proteins.
Statistics
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PSSM-Id: 411036
Aligned: 37 rows
Threshold Bit Score: 99.9986
Created: 14-Nov-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5AJ1_A         11 TFGQKPVKFQLEd---dGEFYMIGSEVGNYLRmFRGSLYKRYPSLWRRLATVEERKKIVASshgkktkpntkdhgyttLA 87   human
RNA33915       10 TIGDKPSSFNFSfddgiTGRFYIGSEVGSHLRlFRGFLYKKYPSLWRRNLTQEERRKLVQLgcs-----------eqnLA 78   Brachionus pl...
GAV05530       52 TFGSRPVSFKLDen--dTEEYYIGSNIGAYLRmFRGQLYRKYPALWKRQTTPEERRKLATMkgvd----------shsVS 119  Ramazzottius ...
CUU99672        6 RYGEKPIEFQLEt---dGEFYYLASDVGRYLRlFRGELHKRYPNLWKRLATQEEREKLIDMgla-----------thvTA 71   Hymenolepis m...
OAF71280      119 TFGEKPKCFKLLd----NEMYYVGSQIGAFLRmFRGILYKKYPGLWRRPITPDERRLVCEKvnfg----------pqsLA 184  Intoshia linei
GAA31071        6 RYGEKPIEFQLEp---dGEYYYLASEVGRYLRlFRKELFKKYPNLWRRLVTPEEKEKLIQMgla-----------shvTA 71   Clonorchis si...
XP_004990134    1 MDDDAPRSFQLCe---gGPRYMVAVEVARYFHqSPEQLFELYPSLYRRQATTAERGTLKRWni--------------sHA 63   Salpingoeca r...
XP_014153911    8 FVVPEPRRFRFGa---eGDVFMLMNQATRFLSkPAGGLLSYHPGLWSRKTTFPERSQLIDQglv------------qaES 72   Sphaeroforma ...
XP_001747455    3 EEGIELRRFSFVp---gGQEYYCATDVARFMGrPLWQFYQLHPSLYRRQATAVERQLLQYWdv--------------aHA 65   Monosiga brev...
KJE94668       11 DAHSLPMRFRSAa---dGVEYMLATSVARHMGrSLVDLFRTYPGLHRRQARDDEWMFLVGKge--------------cFT 73   Capsaspora ow...
5AJ1_A         88 TSVTLLKASEVEEILDGNDEKY 109  human
RNA33915       79 SHLTLVKASEIDEILAGNDEKY 100  Brachionus plicatilis
GAV05530      120 SNTILVKAKEVDEILAGYEEKY 141  Ramazzottius varieornatus
CUU99672       72 QNATILRAIEVDELIGGGEDRF 93   Hymenolepis microstoma
OAF71280      185 TNVILVKHSEIDEILKGNGDKF 206  Intoshia linei
GAA31071       72 MNAMLLRTFEVNDILCGHDDRS 93   Clonorchis sinensis
XP_004990134   64 PIVTLLLAEEVECILEKDDRRL 85   Salpingoeca rosetta
XP_014153911   73 TCVTLVLADEIDEIIKDSLSFT 94   Sphaeroforma arctica JP610
XP_001747455   66 PLVTLLLAEEVDVLRAEDDGAP 87   Monosiga brevicollis MX1
KJE94668       74 TKATLVRAAEIELLAARTANKE 95   Capsaspora owczarzaki ATCC 30864
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