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Dachshund-homology domain found in SKI/DACH domain-containing protein 1 (SKIDA1) and similar proteins SKIDA1 is also known as protein DLN-1. Its biological function remains unclear. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",