6RO4,5A39,2ENK,5LCL


Conserved Protein Domain Family
DBD_XPA-like

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cd21075: DBD_XPA-like 
DNA-binding domain found in DNA repair protein complementing XP-A cells (XPA), yeast DNA repair protein RAD14 and similar proteins
The family includes DNA repair protein complementing XP-A cells (XPA), yeast DNA repair protein RAD14, zinc transporter 9 (ZNT9) and similar proteins. XPA, also known as xeroderma pigmentosum group A-complementing protein (XPAC), is involved in DNA excision repair. It initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Rad14 is involved in nucleotide excision repair. It binds specifically to damaged DNA and is required for the incision step. Rad14 is a component of the nucleotide excision repair factor 1 (NEF1) complex consisting of Rad1, Rad10 and Rad14. ZNT9, also known as solute carrier family 30 member 9 (SLC30A9), may act as a zinc transporter involved in intracellular zinc homeostasis and may also play a role as nuclear receptor coactivator. The model corresponds to the DNA-binding domain found in XPA and Rad14. It consists of a conserved N-terminal zinc-binding subdomain and a C-terminal alpha/beta fold subdomain. ZNT9 contains only C-terminal alpha/beta fold subdomain but lacks of N-terminal zinc-binding subdomain.
Statistics
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PSSM-Id: 410961
Aligned: 128 rows
Threshold Bit Score: 49.1196
Created: 19-Jul-2016
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6RO4_G        137 KLITKTEAKQEYLLkDCDLEKRepplkFIVKKNPHhs---------qwGDMKLYLkLQIVKRSLEVwg-sQEALEEAKEV 206  human
KDQ52597      116 ITMDKTTAMKEFRLrSKDMEGFy----FFTKQSKSvytnkrtkqsvpcPDAHIYFkEDVRQRAIKVhd-gTWESHLKYVA 190  Jaapia argill...
XP_012754612   20 TRIPKTTVKQVYRLtDKELELLk----STKKTNQRf-----------gGAMTLYSrERVLTLCCKKygctRKNIAEVLAQ 84   Acytostelium ...
CEL94062      213 HFLAKTEAMRLGAT-PEELRGLt----FEERANPIsr---------nfPCMKLYRfADVAAVLRLKys-sFDALLAALEC 277  Vitrella bras...
ORY88579       38 ETVCKTPGMKEYGLtAKEIEKIp----YTKARNNYhp---------saAPYKIFQrEDLRVASEKKwg-gVYDPETKTVR 103  Leucosporidiu...
PBK63749       89 LKVLKTEAKKQYKLnDKEMDTLq----YEEDYNPIt-----------rHKSKVFSlPKVQALSLRKhgklPDTVLHELHY 153  Armillaria so...
PRW44573      365 KYVAKSQAQQMYCLtARELDGLp----CEERPNPRnr---------rgPPMKLLAkEDLERAALAKfg-sLAALEAEREK 430  Chlorella sor...
PRW57826      211 QRITKTAAMKEFRLtDKDLGGMs----YTTRRNPIfw---------nsAPTKMYTrLDCLVAAHKKhg-sVQAIQAAATR 276  Chlorella sor...
PRW58438      222 QRLRTTDAEKEYRVtRGELKGLp----FTTEYSYSfw----------aSSIKMFSkLDVLAIAHRKwg-tMAVLDEERAA 286  Chlorella sor...
PSC73962      318 EVVNKSTAQGEFRLtQKELGGLp----YTTRPNPIfw---------haPPVKMYNkLEVLAVAHRKfg-sAGGLAAAKAA 383  Micractinium ...
6RO4_G        207 R 207  human
KDQ52597      191 K 191  Jaapia argillacea MUCL 33604
XP_012754612   85 D 85   Acytostelium subglobosum LB1
CEL94062      278 R 278  Vitrella brassicaformis CCMP3155
ORY88579      104 E 104  Leucosporidium creatinivorum
PBK63749      154 L 154  Armillaria solidipes
PRW44573      431 R 431  Chlorella sorokiniana
PRW57826      277 S 277  Chlorella sorokiniana
PRW58438      287 A 287  Chlorella sorokiniana
PSC73962      384 A 384  Micractinium conductrix
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