6AYE,5W3S


Conserved Protein Domain Family
ELD_TRPML3

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cd21072: ELD_TRPML3 
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 (TRPML3)
TRPML3, also called mucolipin-3 (ML3), acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. It mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. The model corresponds to extracytosolic/lumenal domain (ELD), a linker located between the first two transmembrane segments (S1 and S2) of TRPML3. It forms a tight tetramer that is crucial for full-length TRPML3 assembly and localization.
Statistics
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PSSM-Id: 410968
Aligned: 11 rows
Threshold Bit Score: 291.607
Created: 7-Nov-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
tetramer
Conserved site includes 48 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Structure:6AYE; Homo sapiens TRPML3 extracytosolic/lumenal domain (ELD, also called TRPML I-II linker) forms a tetramer with a four-fold rotational symmetry, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # #  #  ###                  ## #####  #              #    #### ##### #         
6AYE_A        114 RMDDTYAVYTQSDVYDQLIFAVNQYLQLyNVSVGNHAYENKGtkqSAMAICQHFYKrGNIYPGNDTFDIDPEIETECFFV 193  human
5W3S_A        109 RMDDTYAVYTQSDVYDQIIFAVNQYLQLyQVSVGNHAYENKGtdqSAMAICQHFYKrGNIYPGNDTFDIDPEIETDCFFV 188  white-tufted-...
Q8TDD5        109 RMDDTYAVYTQSDVYDQLIFAVNQYLQLyNVSVGNHAYENKGtkqSAMAICQHFYKrGNIYPGNDTFDIDPEIETECFFV 188  human
KFP98655      109 GMDDTYAVYTQRDVYDQIFFAINQYLQLpNISVGNHAYEKRGaeeTALAVCQQFYKrGTICPGNDTFDIDPEIVTDCLYI 188  cuckoo roller
NP_001016804  108 GHDDTYAIYSQEDVHAHINFTIKRYLELqNISVGNHAYESNGkgqTGMSLCQHYYKqGSIFPGNETFEIDPQIDTECFHI 187  tropical claw...
XP_014342641  103 RVDDTYAVYTQADVYDHISFVINRYLKLsHISVGNHAYERKGtnlTAMRLCQNFYAkGSICPGNDTFDIDPKVETECFEI 182  coelacanth
XP_007885391  140 GANNDCVVYTQHDVYEYLSFVISQYIQLhNISVGNHAYERRGshvAPLTVCQYFYKrGSVSPGNETFNVDPKIETDCFNI 219  elephant shark
XP_010770601  107 GGMDSYAVYRQADVYDHIDYIIKQYGHLlNITVGNHAYEKKGdfyTPLSVCQDFYRnGTIYPGNDTFEIDAHVETECFEV 186  black rockcod
KPP70934      140 KNVDTYAVYTKAEVYDHIYFIIDQYANLqNLTVDNHAYERNErgcTPLSICQDVYRnSSIFPENETFYLDPQIDRECVNI 219  Asian bonytongue
XP_023674536  103 RNIENYAVYTKSEVYDHIHFIVDQYVNLwNLSAGNHAYEKDGgkyTPLSICQDFYRkSLIFPENETFHIDPHVESECSDI 182  Paramormyrops...
XP_017328587   86 ERKGIYALYMKQEVHAHIDYIIMRYLTLrSVTVGNHAFQRINgtdTPLILCQRFYTpENISPENQTLSIDPNVQTECVYI 165  channel catfish
Feature 1                               ##           # # ##  #     ##            ######          #
6AYE_A        194 EPdepfhig-tpaenklNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIR 272  human
5W3S_A        189 EPdepfhig-tpaenklNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIR 267  white-tufted-...
Q8TDD5        189 EPdepfhig-tpaenklNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIR 267  human
KFP98655      189 EPttpfdnt-tvgkhnlNFTLDFHRLVTVQLLFSLKAINLQTVRHHELPDCYDFTLTIVFDNKAHSGRIKISLDNDIAIR 267  cuckoo roller
NP_001016804  188 DPstlcsndtpaeyywsNMTLDFYRLVSVEIMFKLKAINLQTIRHHELPDCYDFMVIITFDNKAHSGRIKISLDNDVGIQ 267  tropical claw...
XP_014342641  183 EPlmttddg-tlqenklNLSLDFHRLLKVQIEFRLKAINLQTVRHHELPDCYDFTVMITFDNKAHSGRIKINLENDVGIR 261  coelacanth
XP_007885391  220 VPlvpmhng--slndelNLTLDFHRLLMVQVGFKLKTINLQTIRRHELPDCYYFSIMITFDNKAHSGRIEINLDNDVSIR 297  elephant shark
XP_010770601  187 YPmynpsl----qetlpHFELHFKRLLSVKVTFVLKAINLQTVRHRELPDCYDFTVIITFNNQVHSGRIKVDLENDVDIN 262  black rockcod
KPP70934      220 YPlqslvna-kavrnrlNFTLDFQRLVSINVHLALKAINVQTVQHHELPDCYDFTITVMFNNRAHSGKMKMSLSSDFDMK 298  Asian bonytongue
XP_023674536  183 YPsqlladp-timkkqlNITLDFKRLIRIKIHFALKAINVQTLFHQELPDCYVFAVATTFHNIAQSGRIKMTLNSNTDIK 261  Paramormyrops...
XP_017328587  166 YStkpf--------nitDFTLDFKRLLSLEVRMKIKAINLQTVRHDELPDCYNFGVTVVFDNSAHSGRIKVSLHSGVQIS 237  channel catfish
Feature 1          #######  
6AYE_A        273 ECKDWHVSGS 282  human
5W3S_A        268 ECKDWHVSGS 277  white-tufted-ear marmoset
Q8TDD5        268 ECKDWHVSGS 277  human
KFP98655      268 ECKDWHVSGS 277  cuckoo roller
NP_001016804  268 ECKDWHVSGS 277  tropical clawed frog
XP_014342641  262 ECREWHVSGS 271  coelacanth
XP_007885391  298 ECRGWHIAGA 307  elephant shark
XP_010770601  263 ECRDWKVAGA 272  black rockcod
KPP70934      299 ECKDGEVTEP 308  Asian bonytongue
XP_023674536  262 ECKDGNVTFT 271  Paramormyrops kingsleyae
XP_017328587  238 VCAHADISGS 247  channel catfish

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