Conserved Protein Domain Family
ELD_TRPML2
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cd21071: ELD_TRPML2 
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 2 (TRPML2)
TRPML2, also called mucolipin-2 (ML2), acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. It may activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway. The model corresponds to extracytosolic/lumenal domain (ELD), a linker located between the first two transmembrane segments (S1 and S2) of TRPML2. It forms a tight tetramer that is crucial for full-length TRPML2 assembly and localization.
Links
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Statistics
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PSSM-Id: 410967
Aligned: 9 rows
Threshold Bit Score: 286.986
Created: 13-Nov-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative
Feature 1:putative tetramer interface [polypeptide binding site]
Evidence:
  • Comment:Similarity-based evidence that Homo sapiens TRPML1 (5WJ5) extracytosolic/lumenal domain (ELD, also called TRPML I-II linker) forms a tetramer with a four-fold rotational symmetry.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #   #  ### #               ########                  #       ##  # #       
Q8IZK6        111 GTDEDDYSCSVYTQEDAYESIFFAINQYHQLKDITLGTLGYGENEdn-riGLKVCKQHYkkg--tmFPSNETLNIDnDVE 187  human
XP_018528715   98 GVDEDDYSVAVYTQQDVYDSLFYVLDQYSQLGRLSTGPINYAEDEdgtllPLLICKEYYkrg--svEPPDEAYDIDaQLE 175  barramundi perch
CAG08071       98 GEDQDGYCTAVFTQQDFYHSVFYATEQYSQLGQLSVGPLSYSEDEngnllPFVICKNLYrkr--nlDPSKQVFEIDtELE 175  spotted green...
KPP70934      674 GVDEDDYSIAWYTQQDVHDGLFYLLDQYGNLRNLSVGPVSYAQEDse-slPIVICKELYkk---gsKPFEEYYNIEvQTE 749  Asian bonytongue
XP_015210871  100 GTDEDDYSRAVYSQQDVYDCVFFAIDQYALLKNLSVGPVSYAQDDse-vsPLVICKQHYrrg--svHSSYESNDIDpETE 176  spotted gar
NP_957442     102 GVDEDEYSISIYTKERVFDSLHYVLDQYAQLQNLSVGPISYAEENge-fsPMIICKKSYkrg--dvQPSEDVYDIEaQLE 178  zebrafish
XP_023674750  100 GVDEDDYSIALYTQQAVSDSLFHVIEQYAQLKDLSVGPVNYAQKDdt-wwPIKICKEHYe------KDSEELYNIKaQTE 172  Paramormyrops...
XP_007885392   78 GAREDGNSFAVYNRQDVYDSMFYAINQYLQLHNVTVGNYGYVQDEnn-ltALTVCKQLYvksppvpSENVNRSIIDsRIE 156  elephant shark
XP_014342647   80 GIDEDDYSCSVFTQQDVYESMYFVIDQYQQLKNLSLGTLGYEYDEdk-kaVLKICKKQYkrg--kiVPSNDSFDIEpTIE 156  coelacanth

Feature 1                                                    #   ##      ##             # #####   
Q8IZK6        188 LDCVQLDLqdlskk---ppdwkNSSFFRLEFYRLLQVEISFHLKGIDLQTihsRELPDCYVFQNTIIFDNKAHSGKIKIY 264  human
XP_018528715  176 TVCMSHDPktanl-----wrtqNSSFFELDFYRLVDIKITFQLKGINLQTvrsRELPDCYSFYVTITFDNQCHSGKVKIF 250  barramundi perch
CAG08071      176 KVCLSFDPklvkq-----wkmqNSSFFDLDFYRLIGITVTFQLNGINLQTvrlRELPDCYTFNITINFDNSVHSGKLKIY 250  spotted green...
KPP70934      750 TVCITMNPislqdd---kwkrdNGSFFAVDFYRFINMKITFQLKGVNLHTiraHELPDCYTFFVTIYLDNQGHSGLIKVY 826  Asian bonytongue
XP_015210871  177 TVCLTLDIktiedk---ewkmaNASFFNLDFYRLVNLRISFRLNGINLQTirsHELPDCYEFFITITFDNQGHSGKMKVY 253  spotted gar
NP_957442     179 IVCLTVDPnsilt-----wrmnNASFFELDFYRLVGIEITFALEGINLQTvrsHELPDCCTFFVKIDFDNSCHSGKMKLS 253  zebrafish
XP_023674750  173 KICLEFNPvtlndd---rwkrdNASFFVLDFYRLVNVKITFRLKAVNLQTiqvRELPDCYDFLVTIAFDNHCHSGQIKVY 249  Paramormyrops...
XP_007885392  157 TDCLNIEPfiatnkvsekwemsNSSFFILEFYRLVQIEISFRLKGIDLQAfqyNELPDCYEFLITITFDNTVHSGIIKIF 236  elephant shark
XP_014342647  157 TDCLNIEPvtsakknsavwrmsNTSFYNLEFYRLVQVEITFKLKGIDLQTiqaRELPDCYEFYLSIIFDNQAHSGIVKIY 236  coelacanth

Feature 1          ###     ##  
Q8IZK6        265 FDSDAKIEECKDL 277  human
XP_018528715  251 LDTDAQSSACRDW 263  barramundi perch
CAG08071      251 LNLESSSFACKQW 263  spotted green pufferfish
KPP70934      827 FEMNTVSSACKNW 839  Asian bonytongue
XP_015210871  254 FDSEAISIACKNC 266  spotted gar
NP_957442     254 LGFDAVSSLCKNW 266  zebrafish
XP_023674750  250 FDINALSSICKNW 262  Paramormyrops kingsleyae
XP_007885392  237 LDSDAAIQECNDW 249  elephant shark
XP_014342647  237 FDSDAFLQECKDW 249  coelacanth

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