5WJ5,5TJA,5WPQ,5YE5


Conserved Protein Domain Family
ELD_TRPML1

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cd21070: ELD_TRPML1 
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 1 (TRPML1)
TRPML1, also called mucolipin-1 (ML1), or MG-2, or Mucolipidin, may play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. The model corresponds to extracytosolic/lumenal domain (ELD), a linker located between the first two transmembrane segments (S1 and S2) of TRPML1. It forms a tight tetramer that is crucial for full-length TRPML1 assembly and localization.
Statistics
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PSSM-Id: 410966
Aligned: 10 rows
Threshold Bit Score: 310.965
Created: 13-Nov-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
tetramer
Conserved site includes 40 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Structure:5WJ5; Homo sapiens TRPML1 extracytosolic/lumenal domain (ELD, also called TRPML I-II linker) forms a tetramer with a four-fold rotational symmetry; contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #   #### #              #########                     #    ###  # #   #     
5WJ5_A       112 GADDTFAAYTREQLYQAIFHAVDQYLALPDVSLGRYAYVRgggdpwtNGSGLALCQRYYHRGHVDPANDTFDIDPMVVTD 191 human
5TJA_A        31 GADDTFAAYTREQLYQAIFHAVDQYLALPDVSLGRYAYVRgggdpwtNGSGLALCQRYYHRGHVDPANDTFDIDPMVVTD 110 human
5WPQ_A       112 GSDDTFAAYTQEQLYQAIFYAVDQYLILPEISLGRYAYVRggggpwaNGSALALCQRYYHRGHVDPANDTFDIDPRVVTD 191 house mouse
5YE5_A       112 GSDDTFAAYTQEQLYQAIFYAVDQYLILPEISLGRYAYVRggggpwaNGSALALCQRYYHRGHVDPANDTFDIDPRVVTD 191 house mouse
XP_006002982 108 GADDTYAVYTQSDTYDYIYYTVDQFLTLPNTTVGRYAYVLdk---gvNHSALMLCQHYYKKGRIDPANDTFNIDPQIITA 184 coelacanth
XP_007909912 113 GSDETHAVYTQDDVYSSLFYIIEQFLALQNMTLGTYAYVIen----eNHTALELCQQFYKKGQINPANDTFNINPLVQTE 188 elephant shark
KFQ04670      35 GADDTYAVYTQHDLYDRMFYAMEKYLAIPNETVGRYAYVRges--ggNQSALMLCQQYYRKGRIDPANDTFNIDPKIVTD 112 white-tailed eagle
NP_001315094 127 DSDDALAVYTQSDVYDHMFYAVEQYLSLADTTVGQYAYVYgv---gvNGSALSLCQQYYKKGRIDPANDTFIIDPLVVTD 203 zebrafish
NP_001011347 116 DAEKTYAVYTQEDVYEHLYYAVEQYFSLSNQTTARYAYTRp-----fNQSALSVCQQYYRKGHIDPANDTFNIDPQVITN 190 tropical clawed...
Q9GZU1       112 GADDTFAAYTREQLYQAIFHAVDQYLALPDVSLGRYAYVRgggdpwtNGSGLALCQRYYHRGHVDPANDTFDIDPMVVTD 191 human
Feature 1                                                      #   ## #    ##             #######
5WJ5_A       192 CIQVDPperpppppsddltllessssYKNLTLKFHKLVNVTIHFRLKTINLQSLINNEIPDCYTFSVLITFDNKAHSGRI 271 human
5TJA_A       111 CIQVDPperpppppsddltllessssYKNLTLKFHKLVNVTIHFRLKTINLQSLINNEIPDCYTFSVLITFDNKAHSGRI 190 human
5WPQ_A       192 CIQVDPpdrppdipsedldfldgsasYKNLTLKFHKLINVTIHFQLKTINLQSLINNEIPDCYTFSILITFDNKAHSGRI 271 house mouse
5YE5_A       192 CIQVDPpdrppdipsedldfldgsasYKNLTLKFHKLINVTIHFQLKTINLQSLINNEIPDCYTFSILITFDNKAHSGRI 271 house mouse
XP_006002982 185 CVGVNPltrtyds-------edmdptYKNFTLKFHKLINVTIQFKLKAINIQTIINNEIPDCYTFVITITFDNKAHSGKI 257 coelacanth
XP_007909912 189 CIGVSPstlthp---------tevrmYRNFTLKFYKLINVSIRFKLKAINIQTIINHEIPDCYTFKIQILFDNKAHSGRI 259 elephant shark
KFQ04670     113 CLGVDPedpqplp-------peldrsYKNFTLKFHKLINVTIQFKLKAINIQTIINNEIPDCYTFTITITFDNKAHSGRV 185 white-tailed eagle
NP_001315094 204 CIGVNPlstpta--------agtgrdYRNFTLKFHKLINVTIQFQLKAINLQTIIHNEIPDCYTFLITILLDNKAHSGKV 275 zebrafish
NP_001011347 191 CLFLDPaep--------------sqsYKNFTIKFHKLINLTVQFQLKAINIQTIINNEIPDCYTFTITILFDNKAHSGKV 256 tropical clawed...
Q9GZU1       192 CIQVDPperpppppsddltllessssYKNLTLKFHKLVNVTIHFRLKTINLQSLINNEIPDCYTFSVLITFDNKAHSGRI 271 human
Feature 1            ###     ##       
5WJ5_A       272 PISLETQAHIQECKHPSVFQH 292 human
5TJA_A       191 PISLETQAHIQECKHPSVFQH 211 human
5WPQ_A       272 PIRLETKTHIQECKHPSVSRH 292 house mouse
5YE5_A       272 PIRLETKTHIQECKHPSVSRH 292 house mouse
XP_006002982 258 KIRLENEADIKECKDPNIYGH 278 coelacanth
XP_007909912 260 KVSLDNDVVIKECMDHSVLGY 280 elephant shark
KFQ04670     186 KIRLDNQADIKECKDPSVFGR 206 white-tailed eagle
NP_001315094 276 RISLDNKASIKECRDPSVSGH 296 zebrafish
NP_001011347 257 KIQLDNEAKIKECKDPSVYGR 277 tropical clawed frog
Q9GZU1       272 PISLETQAHIQECKHPSVFQH 292 human

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