6RGN,2EBF,5UQM,5XN7


Conserved Protein Domain Family
toxin_MLD_like
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cd21058: toxin_MLD_like 
membrane localization domain (MLD) of Vibrio MARTX, Pasteurella PMT, clostridial glycosylating cytotoxins, toxin effectors BteA (Bordetella T3SS effector A) and related proteins
This family includes membrane localization domains (MLDs) for toxin effectors such as the Rho-inactivation domain of Vibrio MARTX, Pasteurella mitogenic toxin (PMT), where it has been termed PMT C1 domain, and clostridial glycosylating cytotoxins including Clostridium difficile toxins A (TcdA) and B (TcdB), Clostridium novyi alpha-toxin (TcnA), and Clostridium sordellii lethal toxin (TcsL). It also includes the MLD located in the N-terminal minimal membrane-binding fragment of BteA, a type III secretion system (T3SS) effector protein from Bordetella pertussis, the causative agent of whooping cough.
Links
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Statistics
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PSSM-Id: 411038
Aligned: 4 rows
Threshold Bit Score: 98.0304
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6RGN_A  58 NNDEFVRSVAsprLHHSSEALREVKHDVRQFQASgdr-------slQQLRDLEVALNHWEASQPreFAKRGGMVAELRTA 130 Bordetella pertussis
2EBF_X  53 TPEVLKARASv-iGKPIGESYKRILAKLQRIHNSnild-----erqGLMHELMELIDLYEESQP--SSERLNAFRELRTQ 124 Pasteurella multocida
5UQM_A  25 NRKQLEKMANv-rFRTQEDEYVAILDALEEYHNMsentv---vekyLKLKDINSLTDIYIDTYK--KSGRNKALKKFKEY 98  Clostridioides difficile
5XN7_A  95 SVTELLDAAHv-sGKVRGESYQQVIDALTEYHAStaehadyeltsvEKLLNLRKQVEGYVLGHP--DSGRVQAXNALLNQ 171 Vibrio vulnificus

6RGN_A 131 IDAYKQ 136 Bordetella pertussis
2EBF_X 125 LEKALY 130 Pasteurella multocida
5UQM_A  99 LVTEVL 104 Clostridioides difficile
5XN7_A 172 VNSRLE 177 Vibrio vulnificus
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