3HHW,2K47,3HHZ


Conserved Protein Domain Family
VSV_P-protein-C_like

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cd21033: VSV_P-protein-C_like 
C-terminal domain of Vesicular stomatitis Indiana virus phosphoprotein and related proteins
This family includes the C-terminal domain of the P protein of plant viruses belonging to the Rhabdoviridae animal family such as Vesicular stomatitis Indiana virus (VSV). The family Rhabdoviridae belongs to the order Mononegavirales which are nonsegmented negative-stranded RNA viruses (NNVs). The genomes of NNVs are encapsidated by their nucleocapsid (N) proteins to form N-RNA complexes which serves as a template for transaction and replication. The C-terminus of P protein binds nucleocapsid. P protein plays multiple roles in transcription and translation, which include acting as a chaperone of nascent nucleoprotein (N), and as a cofactor of the viral polymerase (L) where P forms a two-subunit polymerase with a large catalytic subunit (L) and stabilizes the polymerase on its template of N-RNA.
Statistics
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PSSM-Id: 411028
Aligned: 11 rows
Threshold Bit Score: 108.666
Created: 20-Dec-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleocapsid binding site [polypeptide binding site]
Evidence:
  • Structure:3HHZ: C-terminal domain of VSV P protein binds 2 adjacent nucleocapsid (N) proteins within the nucleocapsid; contacts at 4A
    View structure with Cn3D
  • Comment:this binding mode is exclusive to the nucleocapsid, not to the N protein in other existing forms

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           ### ###   #          ## #          #  # ######   ##  
3HHW_A        17 SDVWSLSKT-SXTFQPKKaSLQPLTISLDELFSSRGEFISVGGNGRXsHKEAILLGLRYKKLYNQARVKYSL 87  Vesicular stomatitis In...
2K47_A         1 SDVWSLSKT-SMTFQPKKaSLQPLTISLDELFSSRGEFISVGGDGRMsHKEAILLGLRYKKLYNQARVKYSL 71  Vesicular stomatitis In...
3HHZ_A        17 SDVWSLSKT-SMTFQPKKaSLQPLTISLDELFSSRGEFISVGGNGRMsHKEAILLGLRYKKLYNQARVKYSL 87  Vesicular stomatitis In...
AAA48482     204 TSLWDLRST-EVQLTSKRaGVKDMMVKLTDFFGSEDEYYSVCPEGAPdLMGAIIMGLKHKKLFNQARMKYRL 274 Vesicular stomatitis virus
YP_009505528 201 MDVWEAASQ-VYTLEPKRaNLAPMDVKLKDLFSSRAEFLSVGGSPQMsWKEAIILGLRYKKLYNQARLKYSL 271 Carajas virus
YP_009094098 190 QDVWTLSRK-TQTFLAKKsGVSPLTISLEELFSSRGEFISVGGHGLMtHKDAILLGLRHKRLYNQARVKYHL 260 Vesicular stomatitis Al...
YP_009091826 194 QDVWSLSST-PFTFLPKKqGVTPLTMSLEELFNTRGEFISLGGNGKMsHREAIILGLRHKKLYNQARLKYNL 264 Maraba virus
YP_009362083 199 TDVWSLCQV-SVSFTPRKsGIQPFVISLEELFNSRAEFISVGGNGKMsHKEAILLGLRYKKLYNQARVKYNL 269 Morreton vesiculovirus
AEM60943     193 GDVWALCGK-TKTFPAWKtGVTPLTVTLEELFSSRDEFISVGGHGKMsLKEAIILGLRHKRLYNQARVKYNL 263 Vesicular stomatitis virus
AEM60948     190 QDVWMLSGK-VQAFPAKKpGISPLTISLDELFSSRGEFISVGGHGLMtHKEALLLGLRHKKLYNQARVRYHL 260 Vesicular stomatitis virus
Q91DS2       239 EGLWEVMKVlSVQFDPWKeDEPPLSLTIRDLFISESEFRLHCNHSQT-EREMALVGIKLRRLYNKLYQKYRL 309 Carp sprivivirus

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