C-terminal domain of Rabies virus phosphoprotein and related proteins
This family includes the C-terminal domain of the P protein of plant viruses belonging to the Rhabdoviridae animal family such as Rabies virus (RABV). RABV P protein is known to counteract the functions of various cellular factors involved in antiviral responses, including STAT1, and interferon-induced promyelocytic leukaemia (PML) protein; the C-terminal domain of the RABV P protein includes STAT1 and PML binding sites. The family Rhabdoviridae belongs to the order Mononegavirales which are nonsegmented negative-stranded RNA viruses (NNVs). The genomes of NNVs are encapsidated by their nucleocapsid (N) proteins to form N-RNA complexes which serves as a template for transaction and replication. The C-terminus of P protein binds nucleocapsid. P protein plays multiple roles in transcription and translation, which include acting as a chaperone of nascent nucleoprotein (N), and as a cofactor of the viral polymerase (L) where P forms a two-subunit polymerase with a large catalytic subunit (L) and stabilizes the polymerase on its template of N-RNA.