Conserved Protein Domain Family
polyA_pol_Asfar
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cd20924: polyA_pol_Asfar 
RNA polyadenylate polymerase from the Asfarviridae family of viruses
Poly(A) polymerases (PAPs) catalyze the attachment of adenylates to the 3' ends of messenger RNA and other RNAs, forming poly(A) tails. PAP acts as a nucleic acid template-independent NMP-transferase, preferentially utilizing a single species of NTP, namely ATP. The polyadenylation state of an mRNA may correlate with the efficiency of its translation. The catalytic subunit of NCLDV PAPs contains two topologically identical subdomains with a nucleotidyltransferase fold, suggesting that an ancestral duplication was at the origin of these viral PAPs.
Links
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Statistics
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PSSM-Id: 410848
Aligned: 6 rows
Threshold Bit Score: 433.482
Created: 17-Dec-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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ATP binding
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of Poxviridae family Vaccinia virus poly(A) polymerase catalytic subunit with bound 3'-deoxy ATP at 4A contacts
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          # #                      ## #                                 
P0C9D2        29 EAALEVVREFIIKKKLILYGGIAIDYALHLkgSSIYPEGe--RPDFDMFSPNhveDAYELADILYEKGfkQVGTVRAihv 106 African swine f...
BBO54008      28 WKALDIVKEFCITQELILYGGLGIDFALRKfgDSIYPENe--LPDYDMLSKKnvhDANKLGEMLADYGfnNISVIKGihs 105 Abalone asfarvirus
YP_009361468  28 VDAIEIVKKFIIDNGLIIYGGSAIDYALRLhgDKIYPDDmlqIPDLDFYSYDnveHAYQLADILYEHGfkEARAINAehm 107 Pacmanvirus A23
YP_009352464  26 EKSLEVIREFVIRKGLIIYGGMAINFGLILhgDRIYEDDe--IPDYDVYSSNffeDACELGDILTKAGypNVSVINAkhm 103 Kaumoebavirus
P0C9D5        29 EAALEVVREFIIKKKLILYGGIAIDYALHLkgSSIYPEGe--RPDFDMFSPNhveDAYELADLLYEKGfkQVGTVRAihv 106 African swine f...
TXG80964      27 KKALDIVKQFLIKKKLVLYGGMAMDMAFRLkgSRLYDPAdnkLEDYDFYSPDpinDAYELADILHKEGfpEVNAINAlhv 106 Spirochaetes ba...

Feature 1                      #                                 #  #   #                  #   # 
P0C9D2       107 QTMRVRTDf-vWVADLSYMPPniFDTIPTLTYk------NLKIIHPDYQRAGLHLAFCFPFDNPPREdvfsrfKKDLQRY 179 African swine f...
BBO54008     106 QTMRVRVDf-vPVADISYAPPkiFDLVPTIIYn------GLKIVHPKYQKIDMHLSLSFPFSNPPAEniyhrfKKDVTRH 178 Abalone asfarvirus
YP_009361468 108 ETMRVDIIdnhFIADISYRPReiFNKLPYLEYn------GMKIIHPLFQRLDLHSSLAFPYDNVPREvifsrwSKDVKRF 181 Pacmanvirus A23
YP_009352464 104 TTMKVRINf-ePVLDLTYIPEpiLKKVPYMVYk------NFRFVHPNYQKIDLYRSLSLPLENAPLEniffrwRKDLKRL 176 Kaumoebavirus
P0C9D5       107 QTMRVRTDf-vWVADLSYMPSniFDTIPTLTYk------NLKIIHPDYQRAGLHLAFCFPFDNPPREdvfsrfKKDLQRY 179 African swine f...
TXG80964     107 TTMRVRLGt-kAVADISYIPPniFKVIPTLKFkdptsndTYIIINPLFQRIDLHESLTEPVRDAPTEvyfnrfAKDIKRF 185 Spirochaetes ba...

Feature 1                                                                                        
P0C9D2       180 NLIEKYYPipvvpvkttyes-----ktfsvpfkqvaIHGFAAYALLYQTLNELritc------kapeWKTEFPQPs---- 244 African swine f...
BBO54008     179 NLLCKYYPdeftdtnhqpklyk-nklfipneaknfaLYGFSAYAALIYMYKQLv------------kEPKIPYKFld--- 242 Abalone asfarvirus
YP_009361468 182 NKLDEYYPikapsdklqtre-----mtvptdikkyvLNGFAAYALIYTDFCAMmkefg-----vvptSIKDITSAk---- 247 Pacmanvirus A23
YP_009352464 177 GLLDKYYTlerpeakeakgwkavelpaelsisddiaWGGILAYAIYAYIFQQLfqtyktaavfqrhaSIKTMLKD----- 251 Kaumoebavirus
P0C9D5       180 NLIEKYYPipvvpvkstyen-----ktfsipfkrvaIHGFAAYALLYQTLNELrmtc------kvpeWKTEFPQPs---- 244 African swine f...
TXG80964     186 RMLDELYPieeylpkkypkin--lvdviipelsdilWVGYISYAIHCMQLTELye----------ssSKKIQDKHremfe 253 Spirochaetes ba...

Feature 1                                                                                        
P0C9D2       245 -----------------YSYHKNdknitltvdmpRAYPSLVLATynpeevikemglhlTEICEPYm------DYSPPi-- 299 African swine f...
BBO54008     243 ---------------ldFSYKTEstgvi--ieyeTPEPDHTLIS--------------VNYTSCDffgekteDFAPFvdl 291 Abalone asfarvirus
YP_009361468 248 -----------------FVVTQNqvtfd--tlnqRIEFVHFDMNkmiek----lnisnVKKYEPY-------INMIPeki 297 Pacmanvirus A23
YP_009352464 252 -----------------FPQGVNela-----klnVEKSGKILAIli-----------pTRIIEEAke----kDFQIPlni 294 Kaumoebavirus
P0C9D5       245 -----------------YSYHKNdknitltvdmpKAYPSLVLATynpeeiikemglhlTEICEPYm------DYSPPi-- 299 African swine f...
TXG80964     254 nilqlnitkldsdsqdlYVQIPKs----------RESEPLTMYAddfpdivkklqkqyQLKISYYnt---ylDRSRPrti 320 Spirochaetes ba...

Feature 1                                                                                        
P0C9D2       300 ----------------------------------FKTKDIHFFSTMFKelais----------miqdnIIVVSPQYLLLY 335 African swine f...
BBO54008     292 q-----------------------------nnhsRYNGDTRVYFMPFQcpsig----------rldthINVIGIHYLMVY 332 Abalone asfarvirus
YP_009361468 298 -------------------------------dgsTSFGDITVYSTHNRlvsansv-------ttaditFRVVNVQFLLKY 339 Pacmanvirus A23
YP_009352464 295 lvhrnldtilsgkkyrefeeylalkpeqyvvggkKDPVAIEFYDTSHLlipavspgplmkewgmpninWTVPTIPYLLLY 374 Kaumoebavirus
P0C9D5       300 ----------------------------------FKTKDIHFFSTMFKelais----------miqdnIIVVSPQYLLLY 335 African swine f...
TXG80964     321 k------------------------------lagKQNFEIFDNARSTKtyidvk---------vcgqsMKGASIQLTLMY 361 Spirochaetes ba...

Feature 1                                       
P0C9D2       336 FLygafa-------tpadkSLFLFYYNATLW 359 African swine fever virus Malawi LIL 20/1
BBO54008     333 ILcrkffckilpgaidnsdMYNDYYYFCKQM 363 Abalone asfarvirus
YP_009361468 340 FLa----------------MHFVHKDSAKLS 354 Pacmanvirus A23
YP_009352464 375 FLqryye--------tgmgMFLEFYHGIRDM 397 Kaumoebavirus
P0C9D5       336 FLygafa-------tpadkALFLFYYNATLW 359 African swine fever virus pig/Kenya/KEN-50/1950
TXG80964     362 FLqryf---------ehdnQIHLIYYHHTLQ 383 Spirochaetes bacterium

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