6GVW


Conserved Protein Domain Family
AIR_RAP80-like
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cd20912: AIR_RAP80-like 
ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related domains
RAP80 and ABRAXAS are integral subunits of the BRCA1-A complex which also contains MERIT40 (Mediator of Rap80 Interactions and Targeting 40 kD, also known as BABAM1), BRE (also known as BABAM2, BRCC45 and BRCC4), and BRCC36 (also known as BRCC3). BRCA1-A functions in DNA double-strand break (DSB) repair. RAP80 interacts with the ABRAXAS, MERIT40, and BRE subunits. It is the interaction with ABRAXAS that drives specific incorporation of RAP80 into BRCA1-A. RAP80 contains one SUMO-interacting motif (SIM), two ubiquitin-interacting motifs (UIMs), this AIR, and two zinc finger motifs (ZnF). The SIM and UIM domains recruit BRCA1-A to sites of DNA damage. The AIR is integral in the interaction of RAP80 with the ABRAXAS, MERIT40, and BRE subunits.
Links
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Statistics
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PSSM-Id: 411022
Aligned: 12 rows
Threshold Bit Score: 96.2378
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:ABRAXAS binding site [polypeptide binding site]
Evidence:
  • Structure:6GVW: mouse RAP80 AIR region binds ABRAXAS within the BRCA1-A complex; contacts at 4.0A
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ###### ### # ## #   ## ## ### ##  ##  #                       
6GVW_E          2 GGRHYY-WGIPFCPAGVDPNQYTNVILCQLEVYQKSLKMAQR--QLVKKRGFGEPVLPRPPF 60   house mouse
KGL73032      290 DTVHYY-WGIPFCPKGVDPNQYTKVILCQLEVYQKSLKQAQR--QLLHKKEFGNPVVPSPSS 348  white-throated tinamou
XP_005992394  381 GIVHYY-WGIPFCPKGADPDQYTKVILCQLEVYEKSLKQAQK--QLLRKVEYGNPVLPQSNA 439  coelacanth
NP_001072755  423 STVHYY-WGVPFCPKGEDPNLYTQVILCQLEVYEKSLKKAQR--QLLRKMNFGEPVQLSAPP 481  tropical clawed frog
XP_007889632  259 GLVRYF-WGVPFCPKGVDPDQYTEVILCQLQTYRCCLKVAQR--QLLRKMRFGEPVLPAPMA 317  elephant shark
CDQ64542      637 GVVCYY-WGVPFCPRGQDPDAYTQVIMSQLEVYEKSLKEAQR--GLLRKAGWGEPVLPGPPE 695  rainbow trout
XP_020372695  259 GVVHYF-WGIPFCPSGLDPDQYTRVILCQLETYEQCLKREQS--QLLWKLAFGPPVLPALVP 317  whale shark
XP_006785303  574 TAVHYY-WGVPFCPRGLDPDTYTQVIVAQMEVYEKSLKRAQR--RLLRKAEWGEAVLPATRP 632  Neolamprologus brichardi
XP_003200939  483 RTVTYY-WGVPFCPMGQNPDEYTRVIMCQMEVYEKSLKEAQR--ELLRKADWGKPVCPESPE 541  Danio rerio
XP_013415708  381 KRKLLYkGPSYFAPVGVDPLTYTKVIVQLFDQYRVLLRESQH--NLTEQLSWGKPVEVGRHM 440  Lingula anatina
XP_006825976  249 RRHFSF-SKHLYAPNDVDPNVYTNVIIAMFEQYRLAVKVEQSksFYSCNTFFGTPIKPGYHM 309  Saccoglossus kowalevskii
XP_030842295  463 PRKPNH-KSPFLAPDGVLPNAYTAVILRLFYQYKMRLLKAQA--KQKHRLALGKPVVVGPHV 521  Strongylocentrotus purpuratus

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