Conserved Protein Domain Family
C1_DGKeta_rpt2
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cd20894: C1_DGKeta_rpt2 
second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase eta (DAG kinase eta) and similar proteins
Diacylglycerol (DAG) kinase (EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid. DAG kinase eta, also called diglyceride kinase eta (DGK-eta), plays a key role in promoting cell growth. It is classified as a type II DAG kinase (DGK), containing pleckstrin homology (PH) and sterile alpha motifs (SAM) domains, in addition to C1 and catalytic domains that are present in all DGKs. The SAM domain mediates oligomerization of type II DGKs. The diacylglycerol kinase eta gene, DGKH, is a replicated risk gene of bipolar disorder (BPD). DAG kinase eta contains two copies of the C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410444
Aligned: 11 rows
Threshold Bit Score: 131.177
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Homo sapiens DGKdelta binds two Zn2+ ions
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #            #  #              #  #    #  #       #      
Q86XP1        243 GVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQCK 304  human
KFR17216      180 GIAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKAMVHTACKDLYPRKCPLGQCK 241  Opisthocomus hoazin
OCT92696      259 GIAMPHQWLEGNLPVSAKCDVCDKTCGSVLRLQDWRCLWCKAMVHTACKDQYPRKCPLGQCK 320  African clawed frog
XP_007905368   98 GIAMPHQWLEGNLPVSAKCSVCDKTCGSVLRLQDWRCLWCKAMVHTACKDPFPRKCPLGQCK 159  elephant shark
AAI55553       98 GIAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWRCLWCKAMVHTACMDLYPRKCPLGQCK 159  zebrafish
XP_014349140  274 GIAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWRCLWCKAMVHTACKDPYPRKCPLGQCK 335  coelacanth
XP_013396870  232 AISMPHQWLEGNLPVSAKCVVCDKTCGSVLRLQDWRCLWCKAMVHTSCRETYPKRCPLGQCR 293  Lingula anatina
XP_002603498  196 GIHMPHQWLEGNLPVSAKCSVCDHTCGSVLRLQDWKCLWCRAMVHTTCKEIFPRKCPLGDCR 257  Florida lancelet
KFM73440       98 NIAMPHQWLEGNLPVSAKCSICDKTCGSVLRLQDWKCLWCRAMVHSSCKAQYPEKCPLGVCR 159  Stegodyphus mimosarum
XP_006816467  237 GIAMPHQWLEGNLPVSAKCIVCDKTCGSVLRLQDWRCLWCKVMVHSHCLSQFPTKCPLGQCR 298  Saccoglossus kowalevskii
RUS80948       73 GISMPHQWMEGNLPVSAKCSVCDKTCGSVLRLQDWRCLWCRAMVHSACKEGFGNKCPLGQCR 134  eastern emerald elysia

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