Conserved Protein Domain Family
C1_TNS3_v
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cd20889: C1_TNS3_v 
protein kinase C conserved region 1 (C1 domain) found in tensin-3 (TNS3) variant and similar proteins
Tensin-3 (TNS3), also called tensin-like SH2 domain-containing protein 1 (TENS1), or tumor endothelial marker 6 (TEM6), may play a role in actin remodeling. It is involved in the dissociation of the integrin-tensin-actin complex. This model corresponds to the C1 domain found in TNS3 variant. Typical TNS3 does not contain C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410439
Aligned: 6 rows
Threshold Bit Score: 92.6437
Created: 4-Nov-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Rattus norvegicus ROCK2 binds two Zn2+ ions
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #            #  #           #  #    #  #       #       
BAD92232       29 SLHAFKNKAFKKSKVCGVCKQIIDg-QGISCRACKYSCHKKCEAKVViPCGVQVRLE 84   human
XP_006001791   42 SSHTFKNKTFKKPKSCSICKQVINs-QGISCRVCKYACHKKCETKVVnPCFPPVNYE 97   coelacanth
TFK00972       57 SSHTFKNKTFKKPKDCSICKQAIDs-QGISCRVCKYACHKKCEAKVVkPCFLPINYE 112  big-headed turtle
XP_007895688   38 SSHTFKNKTFKKPKPCSICKQVISnsQGLSCRVCKYACHKKCESKVVtPCLPPVNYE 94   elephant shark
XP_030065125   18 CSHTFKSKSFKKSKVCGICKQVIGs-QGVLCRVCRYTCHKKCEPKVVtPCFLPVNAE 73   Microcaecilia unicolor
XP_028659797   41 SSHTFKTKTFKKPKTCVTCKQVITk-EGVSCRVCRFSCHKKCEAKVVtPCLPLVNYE 96   reedfish

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