Conserved Protein Domain Family
C1_TNS2

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cd20887: C1_TNS2 
protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins
Tensin-2 (TNS2), also called C1 domain-containing phosphatase and tensin (C1-TEN), or tensin-like C1 domain-containing phosphatase (TENC1), is an essential component for the maintenance of glomerular basement membrane (GBM) structures. It regulates cell motility and proliferation. It may have phosphatase activity. TNS2 reduces AKT1 phosphorylation, lowers AKT1 kinase activity, and interferes with AKT1 signaling. It contains an N-terminal region with a zinc finger (C1 domain), a protein tyrosine phosphatase (PTP)-like domain and a protein kinase 2 (C2) domain, and a C-terminal region with SH2 and pTyr binding (PTB) domains. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Statistics
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PSSM-Id: 410437
Aligned: 7 rows
Threshold Bit Score: 79.8242
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Rattus norvegicus ROCK2 binds two Zn2+ ions

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #             #  #          #  #    #  #       #    
Q63HR2         30 EPHSFREKVFRKKpPVCAVCKVTIDgTGVSCRVCKVATHRKCEAKVTsaCQALP 83   human
OPJ67296       25 APHSFREKTFRRG-GACAACREPLGpQGLVCRVCKVTSHKKCETKVTspCQALP 77   Patagioenas fasciata monilis
ETE67114       83 EPHNFKEKVFKKKkKACIVCKESIEaQGLVCRVCKMASHKKCEAKVPssCQPIP 136  king cobra
XP_018105651   27 ERHVFQEKTLKKK-RLCAACSEPVVsQGSVCRVCKITSHKKCEGKVTpgCSTPP 79   African clawed frog
XP_025001270   26 PPHTFQEKSFRKRsRCCAVCRDSVGaHGLLCRVCKIVSHKRCEAKVTspCHPPP 79   chicken
XP_005986202   64 DPHSFKEKAFKKK-KPCAGCKQPVEgQGVTCRVCKVICHKKCESKIPpaCQPPP 116  coelacanth
TKS77077       13 EPHIFKEKTFKKK-RQCSVCRQNVDnVGSFCRVCKTATHRKCEAKVTsaCIPAP 65   big head croaker

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