2FNF,1RFH


Conserved Protein Domain Family
C1_RASSF5

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cd20886: C1_RASSF5 
protein kinase C conserved region 1 (C1 domain) found in Ras association domain-containing protein 5 (RASSF5) and similar proteins
RASSF5, also called new ras effector 1 (NORE1), or regulator for cell adhesion and polarization enriched in lymphoid tissues (RAPL), is a member of a family of RAS effectors, of which there are currently 8 members (RASSF1-8), all containing a Ras-association (RA) domain of the Ral-GDS/AF6 type. It is expressed as three transcripts (A-C) via differential promoter usage and alternative splicing. RASSF5A is a pro-apoptotic Ras effector and functions as a Ras regulated tumor suppressor. RASSF5C is regulated by Ras related protein and modulates cellular adhesion. RASSF5 is a potential tumor suppressor that seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. It contains a C1 domain, which is descibed in this model. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Statistics
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PSSM-Id: 410436
Aligned: 14 rows
Threshold Bit Score: 71.6444
Created: 4-Oct-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Structure:2FNF; Mus musculus RASSF5 binds two Zn2+ ions.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #             #  #          #  #    #  #       # 
2FNF_X        21 GEGHRFVELALrggPGWCDLCGREVLrQALRCANCKFTCHsECRSLIQLDCR 72  house mouse
XP_028853349  96 GEGHRFLSRAVg--RDWCDACGRQVSaEALQCRNCSYTCHlECQGLVQLDCN 145 denticle herring
XP_015137077  27 SAPHRFVPTAT---GAWCDLCCRFVVsQGLRCADCKYTCHaHCRDLVHLGCR 75  chicken
TFK00483     207 GEGHRFEAFALg--RGWCDLCGEAVQqRALRCTNCKYTCHqECRSLIQLDCS 256 big-headed turtle
XP_029428584  52 GQGHRFGRCPGw--RGWCDLCGTPVHgQALRCEHCEYTCHpQCKSLIQLDCS 101 two-lined caecilian
XP_022538440  90 GQGHLFSTHSIa-sPDWCDACARTIRsEARRCKHCSYTCHlECEGLVQLDCN 140 Mexican tetra
XP_028648348  86 GEGHCFTRGAE---QQWCDVCCQLIVtQSLRCTECNYTCHpQCRDKVKLDCN 134 reedfish
XP_026217496 141 GEGHTFEPGGG---DTWCDLCCRYIFeDGLTCTGCKYACHaACRDKVSLDCN 189 climbing perch
XP_018106888  61 VVAHKFQAEAAv--NAWCDLCVHFIFsEALRCSDCKYTCHsHCKDRVHLSCE 110 African clawed frog
XP_029598548 137 GEGHTFNLGLS---GAWCDVCCEYILrFSLMCSGCKYTCHpECRERVSLDCH 185 river trout

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