2DB6


Conserved Protein Domain Family
C1_Stac3
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cd20882: C1_Stac3 
protein kinase C conserved region 1 (C1 domain) found in SH3 and cysteine-rich domain-containing protein 3 (Stac3) and similar proteins
Stac3 is an essential component of the skeletal muscle excitation-contraction coupling (ECC) machinery. It is required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. It plays an essential role for normal Ca2+ release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Stac3 contains a cysteine-rich C1 domain and two SH3 domains at the C-terminus. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410432
Aligned: 7 rows
Threshold Bit Score: 108.892
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Structure:2DB6; Homo sapiens Stac3 binds two Zn2+ ions.
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #            #  #             #  #    #  #        #   
2DB6_A        13 VNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEmQRCSGP 71  human
Q96MF2        85 VNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEmQRCFGK 143 human
Q68F99        55 VNDKPHKFKDHYLKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHHHCQSYVEfQKCFGK 113 tropical clawed frog
Q6DBR6        58 VNDKPHKFKDHYCKKPKFCDVCARMIVLNNKFALRCKNCKTNIHHSCQSYVQfQRCFGK 116 zebrafish
XP_007909647  81 FNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEfQKCFGK 139 elephant shark
XP_005986321  83 VNEKPHKLRDHYLKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHHHCQSYVEqQRCFGK 141 coelacanth
AUI44299      80 VNDKPHKFKDHYFKKPKFCDVCARMIVLNNKFGLRCKNCKTHIHHHCRRYVQlQRCFGK 138 chicken

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