Conserved Protein Domain Family
C1_ARHGEF18-like

?
cd20879: C1_ARHGEF18-like 
protein kinase C conserved region 1 (C1 domain) found in uncharacterized Rho guanine nucleotide exchange factor 18 (ARHGEF18)-like proteins
The family includes a group of uncharacterized proteins that show high sequence similarity to vertebrate ARHGEF18, which is also called 114 kDa Rho-specific guanine nucleotide exchange factor (p114-Rho-GEF), p114RhoGEF, or septin-associated RhoGEF (SA-RhoGEF). ARHGEF18 acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. ARHGEF18 also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Members of this family contain C1, RhoGEF or Dbl-homologous (DH), and Pleckstrin Homology (PH) domains, as well as a DUF5401 domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Statistics
?
PSSM-Id: 410429
Aligned: 6 rows
Threshold Bit Score: 111.058
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Rattus norvegicus ROCK2 binds two Zn2+ ions

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1            #            #  #           #  #    #  #      #   
XP_027699883  348 INGHQLVPGTFsSCINCSLCSKPLLnRNGLQCLNCAVNVHKNCKNLLaDCSNS 400  common wombat
TFK06563      461 VNGHQLAPGTFsSCTSCSLCAKPLVnKNGLQCLNCAVNVHKNCKTLLaECSST 513  big-headed turtle
TRZ01446      346 VSGHQLVPGSFsSCATCSLCSKTLQrKHGLQCLNCAVNVHKSCKNLLpECSGK 398  Danionella translucida
XP_007896975  444 NSGHELMPGTFsSLTNCTVCSKPLTsRNGYQCVNCAVNVHKNCRTLLtECPGR 496  elephant shark
OCU00578      185 TNGHELVPGCFsSHAKCTLCTRALAnRHGLQCMYCAVNVHKNCKTLLpECTSN 237  African clawed frog
XP_023699647  373 SNGHQLVPATVpSGATCSLCNKPLQrRDGLQCHNCGITVHRGCRSLLtECSSR 425  Paramormyrops kingsleyae

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap