Conserved Protein Domain Family
C1_ROCK1

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cd20874: C1_ROCK1 
protein kinase C conserved region 1 (C1 domain) found in Rho-associated coiled-coil containing protein kinase 1 (ROCK1) and similar proteins
ROCK1 is a serine/threonine kinase, catalyzing the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK1, also called Rho-associated protein kinase 1, renal carcinoma antigen NY-REN-35, Rho-associated, coiled-coil-containing protein kinase I (ROCK-I), p160 ROCK-1, or p160ROCK, is preferentially expressed in the liver, lung, spleen, testes, and kidney. It mediates signaling from Rho to the actin cytoskeleton. It is implicated in the development of cardiac fibrosis, cardiomyocyte apoptosis, and hyperglycemia. Mice deficient with ROCK1 display eyelids open at birth (EOB) and omphalocele phenotypes due to the disorganization of actin filaments in the eyelids and the umbilical ring. ROCK proteins contain an N-terminal extension, a catalytic kinase domain, and a C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD), a pleckstrin homology (PH) domain and a C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Statistics
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PSSM-Id: 410424
Aligned: 6 rows
Threshold Bit Score: 175.59
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H H CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Rattus norvegicus ROCK2 binds two Zn2+ ions

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #            #  #               #  #    #  #          #       
Q13464       1222 NFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLIcPCKVSYDVT 1290 human
NP_001243563 1227 NCLPHKGHEFIPTLYHFPTNCEACSKPLWHVFKPPPALECRRCHVKCHKDHLDKKEDMItPCKVNYDVT 1295 zebrafish
OCT74653     1228 NFLNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRKCHVKCHKDHLDKKEELIsPCKVSYDVT 1296 African clawed frog
NP_001186377 1226 NFLNHKGHEFIPTIYHFPANCEACAKPLWHVFKPPAALECRRCHVKCHRDHLDKKEELIaPCKVSYDVT 1294 chicken
XP_007899115 1227 DFIPHKGHEFIPTLYHFPANCEACAKPLWHVFKPPAALECRRCHVKCHKDHLDKKEDMIaPCKVNYDVT 1295 elephant shark
XP_014343725 1227 NFLPHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRKCHVKCHKDHLDKKEDMItPCKMNYDVT 1295 coelacanth

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