Conserved Protein Domain Family
C1_MRCKbeta

cd20865: C1_MRCKbeta

protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase beta (MRCK beta) and similar proteins

MRCK beta, also called Cdc42-binding protein kinase beta (Cdc42BP-beta), DMPK-like beta, or myotonic dystrophy protein kinase-like beta, is a serine/threonine-protein kinase expressed ubiquitously in many tissues. MRCK beta is an important downstream effector of Cdc42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.

Links

Source:	cd20809
Taxonomy:	Gnathostomata
PubMed:	8 links

Protein:	Representatives
	Specific Protein
	Related Protein
	Related Structure
	Architectures
Superfamily:	cl00040

Statistics

PSSM-Id:	410415
Aligned:	6 rows
Threshold Bit Score:	125.096
Created:	7-Oct-2019
Updated:	25-Oct-2021

Structure

Conserved Features/Sites?
PubMed References ?

Zn binding siteputative DAG/PE

Feature 1: Zn binding site [ion binding site], 8 residue positions

Conserved feature residue pattern:H C C C C H C C

Click to see conserved feature residue pattern help

Evidence:

Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
Comment:Based on the structure evidence that Caenorhabditis elegans Dkf-1 binds two Zn2+ ions
Citation:PMID 31406020

Scroll to Sequence Alignment Display

Sequence Alignment

include consensus sequence

Format: Row Display: Color Bits: Type Selection:

Feature 1         #            #  #             #  #    #  #       #   
Q9Y5S2       1026 HQFSIKSFSSPTQCSHCTSLMVGLiRQGYACEVCSFACHVSCKDGAPQVCPIP 1078 human
XP_014344022 1047 HQLTVKNFSSPTQCSHCTSLMVGLvRQGYACDVCSFTCHVSCKDSTPQVCPVP 1099 coelacanth
NP_001165426  979 HQLVIKSFLNPTQCSHCTSLMVGLvRQGYACEVCPFACHVLCKDSAPQVCPIP 1031 African clawed frog
RLW10113      937 HQLSIKSFTSPTQCSHCTSLMVGLvRQGYACDVCSFACHVSCKDSAPQVCPIP 989  Gouldian finch
XP_007886493 1021 HQVSIRTFSSPTQCSHCTSLMVGLvRQGYACDVCSFICHVLCKDNAPQVCPIP 1073 elephant shark
NP_001038590 1022 HQLSIKTFSSPTQCTHCTSLMVGQmRQGYACEVCSFICHVSCKDNAPQLCPIP 1074 zebrafish

Citing CDD

Jiyao W et al.(2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51(D1):D384-D388.

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Conserved Protein Domain FamilyC1_MRCKbeta

Conserved Protein Domain Family
C1_MRCKbeta