Conserved Protein Domain Family
C1_RASGRP4

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cd20863: C1_RASGRP4 
protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 4 (RASGRP4) and similar proteins
RASGRP4 functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. It may function in mast cell differentiation. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Statistics
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PSSM-Id: 410413
Aligned: 6 rows
Threshold Bit Score: 120.653
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
Zn binding siteputative DAG/PE
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Homo sapiens RASGRP1 binds two Zn2+ ions

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #            #  #             #  #    #  #       #    
Q8TDF6       538 AFLHTFHEVTFRKPTFCDSCSGFLWGVtKQGYRCRECGLCCHKHCRDQVkvECKKRP 594 human
NP_001038327 534 HNLHNFHETTYKRPTFCDTCGGFLWGViKQGYHCKDCGVNCHKHCKDVVgmECLKRL 590 zebrafish
XP_005987939 542 GFPHNFQETTYKKPTFCYICTGFFWGVtKQGYRCQGCGINCHKHCMDQVsqECKKRF 598 coelacanth
TFJ99426     576 GFLHDFQEATFKKPTFCHSCNGFLWGVsKQGYRCRDCGRSCHKQCKALVeqECKKRF 632 big-headed turtle
XP_007909266 402 GQRHSFQENTFMRPTFCDMCTGFLWGVtKQGYRCQDCGINCHKQCVEQVtlECKKRT 458 elephant shark
KYO30139      24 APQHHFHTAAFKKPTLCHCCSGLLWGVsKQGYRCQDCGMSCHKQCKELVdvECKRRP 80  American alligator

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