Conserved Protein Domain Family

cd20855: C1_DGK_typeIV_rpt2 
second protein kinase C conserved region 1 (C1 domain) found in type IV diacylglycerol kinases
Diacylglycerol (DAG) kinase (EC is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid. Type IV DAG kinases (DGKs) contain myristoylated alanine-rich protein kinase C substrate (MARCKS), PDZ-binding, and ankyrin domains, in addition to C1 and catalytic domains that are present in all DGKs. The MARCKS domain regulates the nuclear localizations of type IV DGKs while the PDZ-binding and ankyrin domains regulate interactions with several proteins. Two DGK isozymes (zeta and iota) are classified as type IV. DAG kinase zeta, also called diglyceride kinase zeta (DGK-zeta), displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. DAG kinase iota, also called diglyceride kinase iota (DGK-iota), or DGKI, is a homolog of Drosophila DGK2, RdgA. It may have important cellular functions in the retina and brain. Members of this family contain two copies of the C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
PSSM-Id: 410405
Aligned: 26 rows
Threshold Bit Score: 97.4163
Created: 4-Oct-2019
Updated: 25-Oct-2021
Aligned Rows:
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Homo sapiens DGKdelta binds two Zn2+ ions

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1         #            #  #                      #  #    #    #          #   
Q13574        361 HHWVHRRRq-DGKCRHCGKGFQqkftf---hskeiVAISCSWCKQAYHskvsCFMLQQie-epCSLG 422  human
NP_001188565  662 HHWVHRKLe-KGKCKQCGKAVQsklfg----skeiVALACAWCHEIYHnkeaCFNQAKig-eeCRLG 722  fruit fly
NP_001355417  515 HHWVHKWRh-EGRCNTCAKSFQqkmffqgkekketIAVTCSWCKESYHlk-nCFARDKle-erCNRG 578  Caenorhabditis elegans
VDD87811       90 HHWVHKWKl-DGKCLECHKGFQqkrfr----ekelIGVTCTWCKEAYHnkpeCFSQIKld-erCHMG 150  human pinworm
RDD41155      180 HHWVKRKKl-SGKCSKCNKSLSqqgfff-qtsrdfVAIICSWCKVSYHmkepCWTLDLln-eeCNFG 243  Trichoplax sp. H2
TRY74667      142 HHWVKRTNl-KGKCKGCGKSFQgklafg--sskevVGESCSWCKYSYHmkdqCQKDKSqd-dfCCLG 204  Tigriopus californicus
XP_014279423   96 HHWVQHKYekKGKCNFCSKSLQpkklf---sskdlQVSTCSWCKTSFHnrdsCFNSEVmk-gpCNLG 158  brown marmorated stink bug
XP_023345984  165 HHWVIRKQm-KGKCISCHKNFQsklgsk--fssaaVGINCSWCKLALHnsdtCRALVVsn-pvCDLG 227  Eurytemora affinis
GBM42169      107 HHWIARPTp-KGRCRTCGKTFGskvcs---llnetVAMSCSWCKEVCHnkdsCFNPKKmssenCNLG 169  Araneus ventricosus
VVC42150      294 HHWMHRRTq-KDKCSHCGKAFQsvlsf---sskeiIALTCSWCKVSVHnktaCFNDTKmn-epCTLG 355  Cinara cedri

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