Conserved Protein Domain Family
C1_DGKtheta_typeV_rpt3
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cd20854: C1_DGKtheta_typeV_rpt3 
third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
Diacylglycerol (DAG) kinase (EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid. DAG kinase theta, also called diglyceride kinase theta (DGK-theta), is the only isoform classified as type V; it contains a pleckstrin homology (PH)-like domain and an additional C1 domain, compared to other DGKs. It may regulate the activity of protein kinase C by controlling the balance between the two signaling lipids, diacylglycerol and phosphatidic acid. DAG kinase theta contains three copies of the C1 domain. This model corresponds to the third one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410404
Aligned: 25 rows
Threshold Bit Score: 108.506
Created: 4-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Homo sapiens DGKdelta binds two Zn2+ ions
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #             #  #              #  #    #  #            #            
P52824        184 HHWREGNLp-sGARCEVCRKTCGSsDVLAGVRCEWCGVQAHSLCSAALAp-----ECGFGRLRSLVLPP 246  human
RMX60782      164 HHWREGNIp-pSAKCAHCKRTCGSvECLTSVKCCWCGQAAHSSCQFMLPk-----ECGFGYLHKLLLPP 226  Pocillopora damicornis
EFX64421      148 HYWREGNLp-tGAKCILCRKSCWSaECLAGWKCEWCGLAVHSMCYKSVNp-----ECNYGILAPSLLPP 210  common water flea
XP_030538990  273 HHWREGNLpqnSSKCYWCKKSCFSaDCLTGMRCEWCQITVHASCMKNAPr-----DCSLGSLQSIMLPP 336  Rhodamnia argentea
PIK49328       90 HHWRDGNLp-tNSRCVVCKKSCASsECLTGMQCDWCYITAHAGCFKTIPe-----ECDFGSIHELILPP 152  Japanese sea cucumber
XP_028405836  153 HHWQEGNLp-sGSKCFLCKKSCSSsECLASVRCKWCSKTAHSGCYVEINk-----HCDFGKFSHLILPP 215  Dendronephthya gigantea
XP_001626691  165 HHWREGNFs-aSSKCVSCKHSCGSgECLASLKCSWCAQSSHTNCSQLLPk-----ECHYGYLHRVSLPP 227  starlet sea anemone
XP_002605971  153 HLWREGNLv-aAAKCVVCKKNCGTtECLASMRCEWCGVKAHTGCYRSIPa-----ECSFGALQKLMLPP 215  Florida lancelet
TRY72549      158 HHFQEGNLp-hNSKCVKCRKPCWSvDCLIGMRCQWCGLTAHSSCLSFLPns--qsVCQFGQLEPIFLPP 223  Tigriopus californicus
XP_019850293  209 HHWIEGNLt-sHAKCEMCTKPCFTdLCLTGFRCGWCGITLHSSCFNAFIksdkckSCDFRDLSHMILPP 276  Amphimedon queenslandica

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