Conserved Protein Domain Family
C1_DGKepsilon_typeIII_rpt2
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cd20853: C1_DGKepsilon_typeIII_rpt2 
second protein kinase C conserved region 1 (C1 domain) found in type III diacylglycerol kinase, DAG kinase epsilon, and similar proteins
Diacylglycerol (DAG) kinase (EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid. DAG kinase epsilon, also called diglyceride kinase epsilon (DGK-epsilon), is the only isoform classified as type III; it possesses a hydrophobic domain in addition to C1 and catalytic domains that are present in all DGKs, and shows selectivity for acyl chains. It is highly selective for arachidonate-containing species of DAG. It may terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition. DAG kinase epsilon contains two copies of the C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410403
Aligned: 21 rows
Threshold Bit Score: 98.8889
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Homo sapiens DGKdelta binds two Zn2+ ions
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #            #  #              #  #    #  #          #            
1708625      125 HHWIRGNVPlCSYCMVCKQQCGcqpkLCDYRCIWCQKTVHDECMKNSLkn-ekCDFGEFKNLIIPP 189 human
XP_013387424 107 HHWVHGNLPlSSRCCICGELCGirpeLCDFRCCWCQRTIHEECRHENAgyiqiCDLGAFKDFIVPP 172 Lingula anatina
RUS79325     104 HHWVQGNLPpYSECLVCGEECGvlkpLADLRCSWCKATAHDGCAAKTEv----CDLGRYRRFIVPP 165 eastern emerald elysia
ELT89209     102 HHWLRGNLPhCSKCNVCGEDCGnlpqLCDLRCCWCCRHIHERCLKNASe---vCDLGYYKDCIVPP 164 Capitella teleta
EFX86572     101 HQWVKGNLPpESICHVCEEDCDterhFSDFRCCWCQWTVHEKCLANLAd---lCNLGTYRNFIIPP 163 common water flea
OZC10331     104 HHWVHGNLPpFSVCGVCNEECGdgvgLIDLRCSFCQFTVHSHCRQLVDk---rCTMGANWDFIVPP 166 Onchocerca flexuosa
EEC01939     102 HHWVKGNTSpNSLCTVCEKLCGleaaLVDFRCCWCQRTVHTKCADQLGn---vCDLGSHRAFVVPP 164 black-legged tick
XP_009022596 130 HHWIIGNVPaDLKCTVCNVLIGssdkLCHFKCCWCKRAVHMLCKKLSSn---tCDMGHMKDWVVPP 192 Helobdella robusta
NP_001024679 110 HHWICGNIGaDLFCEVCEELCGgv-gLQDFRCSWCWRVVHTKCKPKFTk---hCDFGGLKRTIIPP 171 Caenorhabditis elegans
KOF87990     105 HQWGHGNLPlYSICYICNEPCNnqlqLCDYICSWCQRCVHTECFTHCKk---eCDLGPYKTVIVPP 167 Octopus bimaculoides

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