Conserved Protein Domain Family

cd20852: C1_DGK_typeII_rpt2 
second protein kinase C conserved region 1 (C1 domain) found in type II diacylglycerol kinases
Diacylglycerol (DAG) kinase (EC is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid. Type II DAG kinases (DGKs) contain pleckstrin homology (PH) and sterile alpha motifs (SAM) domains, in addition to C1 and catalytic domains that are present in all DGKs. The SAM domain mediates oligomerization of type II DGKs. Three DGK isozymes (delta, eta and kappa) are classified as type II. DAG kinase delta, also called 130 kDa DAG kinase, or diglyceride kinase delta (DGK-delta), is a residential lipid kinase in the endoplasmic reticulum. It promotes lipogenesis and is involved in triglyceride biosynthesis. DAG kinase eta, also called diglyceride kinase eta (DGK-eta), plays a key role in promoting cell growth. The DAG kinase eta gene, DGKH, is a replicated risk gene of bipolar disorder (BPD). DAG kinase kappa is also called diglyceride kinase kappa (DGK-kappa) or 142 kDa DAG kinase. Members of this family contain two copies of the C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
PSSM-Id: 410402
Aligned: 24 rows
Threshold Bit Score: 89.6889
Created: 7-Oct-2019
Updated: 25-Oct-2021
Aligned Rows:
Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Structure:1R79; Homo sapiens DGKdelta binds two Zn2+ ions.
    View structure with Cn3D

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1         #            #  #               #  #    #  #              #   
XP_004364925  315 HQWIMGNLPgSSRCAVCEKGCGssk-rlADYRCLWCQQTVHSGCLSTAVv-------eCTLG 368  Capsaspora owczarzaki ATCC 30864
NP_501476     121 HQWMEGNLPmPSKCSVCEKPCGsvr-klIDYRCIWCGCCVHDTCIGNLAr-------aCSLG 174  Caenorhabditis elegans
XP_009019283  216 HQWQMGNFPaNSKCLVCKKSCGsml-rlQDLSCLWCQATVHSGCQHKTPt--------CNLG 268  Helobdella robusta
XP_003382870  125 HAWIRGNLPlASRCFKCLTPCGtvp-alADYRCLWCHNTVHEDCIDEEKgegrrergdCTLG 185  Amphimedon queenslandica
TPX66194      186 HQWVEGNLSlGARCQVCYASAGsep-tlKDMRCIWCDVTVHTTCFTQYRt-------kCPLG 239  Spizellomyces sp. 'palustris'
XP_028401604  234 HQWMQLNIPpGSKCYVCDKSCGgrk-npQDRKCLWCGLSVHSFCESPTAar-----akCSLG 289  Dendronephthya gigantea
CBY22072       90 HQWLVGNIPvNSKCAACKKACGsilrlsEDRRCLWCRDIYHAQCIGGHLr--------CSFG 143  Oikopleura dioica
RKO88130       30 HQWVEGNLPlNAVCTVCTVAAGsep-alADFRCVWCQHTVHTACLADLEg-------pCPLS 83   Blyttiomyces helicus
XP_019863877  288 HQWMEGNLPsGSKCSVCKRACGsli-rlQDFRCLWCKGTVHADCKDSVTt-------pCTLG 341  Amphimedon queenslandica

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