Conserved Protein Domain Family
C1_DGKeta_rpt1
?
cd20848: C1_DGKeta_rpt1 
first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase eta (DAG kinase eta) and similar proteins
Diacylglycerol (DAG) kinase (EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid. DAG kinase eta, also called diglyceride kinase eta (DGK-eta), plays a key role in promoting cell growth. It is classified as a type II DAG kinase (DGK), containing pleckstrin homology (PH) and sterile alpha motifs (SAM) domains, in addition to C1 and catalytic domains that are present in all DGKs. The SAM domain mediates oligomerization of type II DGKs. The diacylglycerol kinase eta gene, DGKH, is a replicated risk gene of bipolar disorder (BPD). DAG kinase eta contains two copies of the C1 domain. This model corresponds to the first one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
?
Statistics
?
PSSM-Id: 410398
Aligned: 5 rows
Threshold Bit Score: 173.427
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Homo sapiens DGKdelta binds two Zn2+ ions
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                      #            #  #             #  #    #  #       # 
Q86XP1        147 EDWISSLKSVQtrEPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCK 226  human
OCT92696      163 EDWISSLKSVQsrEHYETAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCK 242  African clawe...
AAI55553        2 EDWISSLKSVQsrEHYETAQFNVEHFSGMHNWYACSHARPTFCNVCRDSLSGVTSHGLSCEVCKFKAHKRCAVRATNNCK 81   zebrafish
XP_007905368    2 EDWITSLKSVQsrEHYETAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRAINNCK 81   elephant shark
KFR17216       84 EDWISSLKSVQsrEHYETAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCK 163  Opisthocomus ...

Feature 1               
Q86XP1        227 WTTLAS 232  human
OCT92696      243 WTTLAS 248  African clawed frog
AAI55553       82 WTTLAS 87   zebrafish
XP_007905368   82 WTTLAS 87   elephant shark
KFR17216      164 WTTLAS 169  Opisthocomus hoazin

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap