Conserved Protein Domain Family
C1_DGKgamma_rpt1

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cd20846: C1_DGKgamma_rpt1 
first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase gamma (DAG kinase gamma) and similar proteins
Diacylglycerol (DAG) kinase (EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid. DAG kinase gamma, also called diglyceride kinase gamma (DGK-gamma), reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid. It is classified as a type I DAG kinase (DGK), containing EF-hand structures that bind Ca(2+) and a recoverin homology domain, in addition to C1 and catalytic domains that are present in all DGKs. As a type I DGK, it is regulated by calcium binding. DGK-gamma contains two copies of the C1 domain. This model corresponds to the first one. DGK-gamma contains typical C1 domains that bind DAG and phorbol esters. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Statistics
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PSSM-Id: 410396
Aligned: 5 rows
Threshold Bit Score: 152.393
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
Zn binding siteputative DAG/PE
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Homo sapiens DGKdelta binds two Zn2+ ions

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                          #            #  #             #  #    #  #       #       
P49619        255 LLVLLGMDdsgsKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPgCVKTYSKA 328  human
TSM68911      318 LLVLLGMEtn-vQEDGQHVWRLKHFNKPAYCNFCHTMLLGVRKQGLCCSLCKYTVHERCVSKDIAaCISTYAKS 390  goonch
TFK11130      341 LLVLLGMEtn-vKDDGQHAWRLKHFKKPAYCNFCRTMLLGVRKQGLCCSFCKYTVHERCVSKDIAsCISTYVKS 413  big-headed turtle
XP_014342895  226 LLVLLGMEtn-vKDDGQHVWRLKHFKKPAYCNFCHNMLMGVRKQGLCCSFCKYTVHERCVSKDIAtCISTYVKS 298  coelacanth
XP_007898286  339 LLVLLGMEtn-vKDDGQHFWRLKHFNKPAYCNFCLNMLLGVRKQGLCCAFCKYTVHERCVSKPIAsCISTYVKS 411  elephant shark

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