Conserved Protein Domain Family
C1_PKD2_rpt2

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cd20843: C1_PKD2_rpt2 
second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins
PKD2, also called PRKD2, HSPC187, or serine/threonine-protein kinase D2 (nPKC-D2), is a serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. PKD2 contains N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Statistics
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PSSM-Id: 410393
Aligned: 5 rows
Threshold Bit Score: 177.859
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
Zn binding siteputative DAG/PE
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Caenorhabditis elegans Dkf-1 binds two Zn2+ ions

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    #            #  #             #  #    #  #       #                   
Q9BZL6        254 DKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGd---vPMEEAT 330  human
XP_030073235  172 DKLLMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGETVFNGd---vPMEDCS 248  Microcaecilia...
TFJ98645      245 DKLFLSKVKVPHTFLIHSYTRPTVCQFCKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGETLFNGgd--vPMEDAS 322  big-headed tu...
XP_006000496  255 DKMLMSKVKVPHTFVVHSYTRPTVCQYCKKLLKGLFRQGLQCKDCKFNCHKRCLTKIPNDCLGEAVFNGdlmspGTEADV 334  coelacanth
RXM27497      568 DKMLLSKVKVPHTFEVHSYTRPTVCQFCKKLLKGLFRQGLQCKDCKFNCHKRCALKVPNDCLGETLINGdllspSVDAEM 647  sterlet
Feature 1          
Q9BZL6        331 D 331  human
XP_030073235  249 D 249  Microcaecilia unicolor
TFJ98645      323 D 323  big-headed turtle
XP_006000496  335 T 335  coelacanth
RXM27497      648 P 648  sterlet

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