Conserved Protein Domain Family
C1_dGM13116p-like
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cd20831: C1_dGM13116p-like 
protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and similar proteins
This group contains uncharacterized proteins including Drosophila melanogaster GM13116p and Caenorhabditis elegans hypothetical protein R11G1.4, both of which contain C2 (a calcium-binding domain) and C1 domains. This model describes the C1 domain, a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410381
Aligned: 21 rows
Threshold Bit Score: 90.863
Created: 14-Nov-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Rattus norvegicus ROCK2 binds two Zn2+ ions
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #             #  #              #  #    #  #         #  
AAL13712      863 HIYNDHTFIAKHLSgsgLQCSICMKSIPRRpGKQGYECRDCQLICHKqCHIRAp--qACPN 921  fruit fly
PFX26653      856 HIYNDHIFTAVHFTgspPECAVCTKPIKGKiGKQGYQCRECKLVTHRdCHYQTt--tMCSS 914  Stylophora pistillata
7506647      1175 HIYNDHTFVAVKVKg-gATCNVCQQRIRSSfSKQAYQCRDCKMVCHKtCHYKTd--aFCTQ 1232 Caenorhabditis elegans
KJE90355     1326 HLVNNHMFRATHFNs-lPQCKLCTKLLVGI-GKQGYRCERCGAVCHKqCHETLp---ACAI 1381 Capsaspora owczarzaki ATCC 30864
KRY70193      570 HIFNEHTFVATKVTt-gHFCSVCMKTVRSTfRKQGYRCRDCRMLCHKrCHYKTe--tHCPS 627  Trichinella pseudospiralis
XP_004365733  730 HVCNGHTFVATHFPs-kESCAVCNQSLKGSfGKQGYQCRECRTICHKeCHRTVa--sWCSA 787  Capsaspora owczarzaki ATCC 30864
XP_001623417  695 HVYNEHMFRADHLGe-tTECAVCAKSIIRKpGKQAYRCKDCKMTCHKrCHSQTt--vICSS 752  starlet sea anemone
XP_014671620  125 HMFNNHMFSASHVAg-gTACQACGMLIPRKfGRQGYVCRDCMMVVHKpCHCRLstelTCPK 184  Priapulus caudatus
XP_017462078   60 HVFNDHLFVAQHVSs-sQECAVCAKTFPMRiGKQGYVCRECGFLTHKlCHVNVe--sYCPA 117  snowberry fruit fly
XP_009497948  932 HLAMGHRFRATHFNk-lVSCAVCNSTLLGI-GKQGYRCQDCSLICHKkCHASAp---ACAS 987  Fonticula alba

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