Conserved Protein Domain Family
C1_MTMR-like
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cd20828: C1_MTMR-like 
protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to myotubularin-related proteins
The family includes a group of uncharacterized proteins that show high sequence similarity to vertebrate myotubularin-related proteins (MTMRs), such as MTMR5 and MTMR13. MTMRs may function as guanine nucleotide exchange factors (GEFs). Vertebrate MTMR5 and MTMR13 contain an N-terminal DENN domain, a PH-GRAM domain, an inactive PTP domain, a SET interaction domain, a coiled-coil domain, and a C-terminal PH domain. Members of this family contain these domains and have an additional C1 domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410378
Aligned: 8 rows
Threshold Bit Score: 120.626
Created: 15-Nov-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Rattus norvegicus ROCK2 binds two Zn2+ ions
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #            #  #                #  #    #  #       #  
RDD42865     1946 SFTHPHNFEVHNFLaPLYCDYCMQILWGLv---kQGMKCSDCGYNCHEKCAPLVPWQCSK 2002 Trichoplax sp. H2
XP_028416443 1799 GFTQPHTFEPHSFVaPTNCDFCLQMMWYIg---kGGFKCKECGFNCHEKCLSRVPQACRY 1855 Dendronephthya gigantea
XP_030845368 1713 GFNFPHHFEPCSYMtPTSCDFCNQMLFGVvkqgcTGMKCSDCGYNVHEKCVPQVPKQCSR 1772 purple sea urchin
PFX31011     2612 GFSQPHNFEPHLFVpPSNCEHCLQLIIGIl---nKGVKCTECGYNCHEKCQPQVPWQCKK 2668 Stylophora pistillata
KXJ12124     1645 GFSQPHNFTKHTFLtPTNCDYCLQIIIGFv---sKGLKCTECGYNVHEKCQSQVPWQCKK 1701 Exaiptasia pallida
XP_002739269  404 SHTQPHNFEPHSYVtPTYCDYCQRILWGIvkqgyKGMNCRECGYNCHDKCQHLVPKQCGK 463  Saccoglossus kowalevskii
PIK47555      480 GFTYQHRFEPHNFInPQNCDYCQQLLYGVvkqgvKGMKCSDCGYNAHDSCIPSIPKQCRR 539  Japanese sea cucumber
XP_030845369 1765 GFNFPHHFEPCSYMtPTSCDFCNQMLFGVvkqgcTGMKCSDCGYNVHEKCVPQVPKQCSR 1824 purple sea urchin

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