Conserved Protein Domain Family
C1_PDZD8
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cd20825: C1_PDZD8 
protein kinase C conserved region 1 (C1 domain) found in PDZ domain-containing protein 8 (PDZD8) and similar proteins
PDZD8, also called Sarcoma antigen NY-SAR-84/NY-SAR-104, is a molecular tethering protein that connects endoplasmic reticulum (ER) and mitochondrial membranes. PDZD8-dependent ER-mitochondria membrane tethering is essential for ER-mitochondria Ca2+ transfer. In neurons, it is involved in the regulation of dendritic Ca2+ dynamics by regulating mitochondrial Ca2+ uptake. PDZD8 also plays an indirect role in the regulation of cell morphology and cytoskeletal organization. It contains a PDZ domain and a C1 domain. This model describes the C1 domain, a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410375
Aligned: 27 rows
Threshold Bit Score: 87.7187
Created: 4-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Rattus norvegicus ROCK2 binds two Zn2+ ions
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #               #  #           #  #    #  #           #  
Q8NEN9        838 ENKHSFQDTQFq---nPTWCDYCKKKVWtKAASQCMFCAYVCHKKCQEKCLae-tsVCGA 893  human
XP_013077004  696 EGHHQFDSTNFt---tATFCDFCGKKIWmKEAFKCKICQMVCHRKCLAKCLin--tICTE 750  Biomphalaria glabrata
NP_572771     722 PRAHDFVRTHFh---rATQCDFCGKKIWlKDAMQCQECSMCCHKKCIVKCQma--tVCGP 776  fruit fly
EFX86131      614 MPMHNFVLTQFi---nVRLCDFCRKKIWlREALQCRNCELVCHKKCIKRYPdr--kWCGL 668  common water flea
XP_004365966 1041 DKWHRFVLQTFp---vAPYCRFCSGKVWrMEAFRCELCKYVCHKKCLHNCLrq--tLCLG 1095 Capsaspora owczarzaki ATCC 30864
RXG74033      206 ERDHVFKRTHFn---sATQCSFCKKKIWlKDAYQCSECGIICHKKCMLRCQqa--tVCDY 260  common pillbug
OXA44086      805 YQSHQFVRTNFr---cATICDYCNKKIWlKEAFACRTCHMKCHKKCNDRCIan--tICRG 859  Folsomia candida
XP_014783225  369 IENHKFVVNCTpyqsaSYCCVFCARKIWmGRGFKCNVCGMIVHKKCTDKCQek--tLCTR 426  Octopus bimaculoides
EFX86420      895 KRPHDWTLRRFg---qLQNCDICQSKIWlGEGLYCPRCGLIIHKKCFKRIItenrkWCSV 951  common water flea
PIK51948      779 QRLHVFLGTHFs---mPTRCDFCTKKVWtKFAYQCQGCHLICHKKCSDKTQin--iPCDR 833  Japanese sea cucumber

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